Ding Dayong, Feng Ye, Song Bin, Gao Shuohui, Zhao Jisheng
Department of Gastrointestinal Surgery, Jilin University China-Japan Union Hospital, Changchun, China.
Turk J Gastroenterol. 2015 Mar;26(2):181-5. doi: 10.5152/tjg.2015.3993.
BACKGROUND/AIMS: Effects of preoperative one week enteral nutrition (EN) support on the postoperative nutritional status, immune function and inflammatory response of gastric cancer patients were investigated.
106 cases of gastric cancer patients were randomly divided into preoperative one week EN group (trial group) and early postoperative EN group (control group), which were continuously treated with EN support until the postoperative 9th day according to different treatment protocols. All the patients were checked for their body weight, skinfold thickness, upper arm circumference, white blood cell count (WBC), albumin (ALB), prealbumin (PA), C-reactive protein (CRP), humoral immunity (IgA, IgG), T cell subsets (CD4, CD8 and CD4/CD8), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), etc. on the preoperative and the postoperative 1st and 10th day, respectively.
PA and IgG levels of the experimental group were higher than those of the control group on the postoperative 10th day, whereas IL-6 level of the experimental group was lower than that of the control group.
EN support for preoperative gastric cancer patients will improve the postoperative nutritional status and immune function, alleviate inflammatory response, and facilitate the recovery of patients.
背景/目的：探讨术前一周肠内营养（EN）支持对胃癌患者术后营养状况、免疫功能及炎症反应的影响。
将106例胃癌患者随机分为术前一周EN组（试验组）和术后早期EN组（对照组），根据不同治疗方案持续给予EN支持至术后第9天。分别于术前、术后第1天和第10天对所有患者进行体重、皮褶厚度、上臂围、白细胞计数（WBC）、白蛋白（ALB）、前白蛋白（PA）、C反应蛋白（CRP）、体液免疫（IgA、IgG）、T细胞亚群（CD4、CD8和CD4/CD8）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）等检查。
术后第10天，试验组PA和IgG水平高于对照组，而试验组IL-6水平低于对照组。
对术前胃癌患者给予EN支持可改善术后营养状况和免疫功能，减轻炎症反应，促进患者康复。
