School of Public Health, Faculty of Health Sciences, Curtin University, WA, Australia.
Curtin Health Innovation Research Institute, Curtin University, WA, Australia.
Asia Pac J Clin Nutr. 2020;29(3):537-544. doi: 10.6133/apjcn.202009_29(3).0012.
As the incidence and prevalence of Alzheimer's disease increases, so does the body of epidemiological and clinical research that suggests a relationship between dietary fatty acids, in particular saturates, and cognitive decline. In this study, we investigated the association between serum apolipoprotein B48 (apoB48), saturated fatty acid intake and consumption behaviour, and cognitive performance, in healthy, older aged Australians.
We retrospectively analysed fasted serum apoB48 concentrations, food frequency questionnaire, and cognitive performance data collected from 147 participants (98F|49M) over the age of 50. We used Spearman's correlations and a nested domain model to evaluate the relationship between serum apoB48, dietary behaviour and measures of cognitive performance.
Overall, we found that higher fasted apoB48 concentrations, and/or dietary behaviours which led to increased dietary consumption of diets high in saturated fatty acids, were inversely associated with cognition. Interestingly however, dietary behaviour patterns of saturated fatty acid consumption and serum apoB48 were linked with better secondary memory and perceptual speed, respectively.
This is the first time that fasted apoB48 has been implicated as a biomarker for cognitive decline and Alzheimer's disease risk.
随着阿尔茨海默病的发病率和患病率的增加，越来越多的流行病学和临床研究表明，膳食脂肪酸（尤其是饱和脂肪酸）与认知能力下降之间存在关联。在这项研究中，我们调查了在健康的澳大利亚老年人中，血清载脂蛋白 B48（apoB48）、饱和脂肪酸摄入和消费行为与认知表现之间的关系。
我们回顾性分析了 147 名年龄在 50 岁以上的参与者（98 名女性，49 名男性）的空腹血清 apoB48 浓度、食物频率问卷和认知表现数据。我们使用 Spearman 相关分析和嵌套域模型来评估血清 apoB48、饮食行为与认知表现之间的关系。
总的来说，我们发现较高的空腹 apoB48 浓度，以及/或导致饮食中饱和脂肪酸摄入量增加的饮食行为，与认知能力呈负相关。然而，有趣的是，饱和脂肪酸摄入和血清 apoB48 的饮食行为模式分别与较好的二级记忆和知觉速度相关。
这是首次发现空腹 apoB48 可作为认知能力下降和阿尔茨海默病风险的生物标志物。
