Department of Endocrinological Surgery, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Clinical Nutrition, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Asia Pac J Clin Nutr. 2020;29(3):603-608. doi: 10.6133/apjcn.202009_29(3).0020.
The relationship between nutritional status of iodine and thyroid tumor is unclear. We investigated the association between urinary iodine concentration and thyroid function in patients with papillary thyroid cancer, benign thyroid tumor and healthy individuals.
We compared the biomarkers of thyroid function and urinary iodine concentration within and between each group. A regression analysis was used to identify risk factors for papillary thyroid cancer. Correlation analysis was performed to determine whether any significant correlation exists between urinary iodine concentration and thyroid function biomarkers.
The iodine nutrition statuses of these three groups were adequate (median urinary iodine concentration= 100-199 μg/L). However, the median urinary iodine concentration of papillary thyroid cancer (174.7 μg/L) and benign thyroid tumor (165.04 μg/L) groups was significantly higher than that of the healthy control group (135.8 μg/L) (p<0.05). The regression analysis showed that thyroglobulin antibody was an independent risk factor for papillary thyroid cancer. After adjusting for age and gender, the association between thyroglobulin antibody and urinary iodine concentration was significant (β: 0.002; p<0.05). In subgroup analyses, significant correlations was noted only in the papillary thyroid cancer group (adjusted β: 0.002; 95% confidence interval: 0.000- 0.003).
Excessive iodine in patients with thyroid tumors may affect thyroglobulin antibody, which may be an independent risk factor for papillary thyroid cancer.
碘的营养状况与甲状腺肿瘤之间的关系尚不清楚。我们研究了甲状腺癌患者、良性甲状腺肿瘤患者和健康个体的尿碘浓度与甲状腺功能之间的关系。
我们比较了每组内和组间甲状腺功能和尿碘浓度的生物标志物。采用回归分析确定甲状腺癌的危险因素。进行相关性分析以确定尿碘浓度与甲状腺功能生物标志物之间是否存在显著相关性。
三组碘营养状况充足（中位数尿碘浓度=100-199μg/L）。然而，甲状腺癌（174.7μg/L）和良性甲状腺肿瘤（165.04μg/L）组的中位数尿碘浓度明显高于健康对照组（135.8μg/L）（p<0.05）。回归分析显示，甲状腺球蛋白抗体是甲状腺癌的独立危险因素。在校正年龄和性别后，甲状腺球蛋白抗体与尿碘浓度之间存在显著相关性（β：0.002；p<0.05）。在亚组分析中，仅在甲状腺癌组中观察到显著相关性（调整后的β：0.002；95%置信区间：0.000-0.003）。
甲状腺肿瘤患者体内碘过量可能会影响甲状腺球蛋白抗体，后者可能是甲状腺癌的独立危险因素。
