Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Republic of Tatarstan, Russia.
Bull Exp Biol Med. 2020 Sep;169(5):635-638. doi: 10.1007/s10517-020-04943-1. Epub 2020 Sep 29.
The study examined the effect of α-adrenoreceptor (α-AR) activation against the background of preliminary blockage of I on the performance of Langerndorff-isolated rat heart. Stimulation of α-AR in isolated rat hearts against the background of ZD7288 in concentrations of 10 M and 3×10 M changed the negative dynamics of myocardial inotropy to positive (by 25 and 38%; p<0.05). Activation of α-AR produced opposite effects on HR. I blockade abolished tachycardia caused by activation of α-AR; HR deceleration in response to α-AR agonist against the background of I blocker in a concentration 10 M was 41% (p<0.05). We observed negative dynamics of coronary flow (by 38%; p<0.05) in isolated adult rat hearts after application of α-AR agonist against the background of I blockade (10 M).
这项研究考察了在初步阻断 I 的背景下，α-肾上腺素能受体 (α-AR) 激活对 Langendorff 分离大鼠心脏功能的影响。在 ZD7288 浓度为 10 μM 和 3×10 μM 的情况下，刺激分离的大鼠心脏中的 α-AR 将心肌收缩力的负性动力学转变为正性（分别增加 25%和 38%；p<0.05）。α-AR 的激活对 HR 产生相反的影响。I 阻断消除了激活 α-AR 引起的心动过速；在 10 μM 的 I 阻断剂背景下，α-AR 激动剂引起的 HR 减速为 41%（p<0.05）。我们观察到，在应用 I 阻断剂（10 μM）的背景下，α-AR 激动剂对成年大鼠心脏冠状动脉流量产生负性动力学（减少 38%；p<0.05）。
