伴有痴呆的布瑞哌唑相关 Pisa 综合征（角弓反张）
Brexpiprazole-Associated Pisa Syndrome (Pleurothotonus) in a Patient With Dementia.
出版信息
Clin Neuropharmacol. 2022;45(3):72-73. doi: 10.1097/WNF.0000000000000500. Epub 2022 Apr 14.
OBJECTIVES
The aims of the study were to report brexpiprazole-induced Pisa syndrome (PS) in a patient with Alzheimer disease and to discuss the pathophysiology and the treatment of PS.
METHODS
We report a 71-year-old female patient with Alzheimer disease. After 2 months medication of brexpiprazole, she presented PS. By switching to quetiapine, the symptom was ameliorated; however, transient acute dystonia was occurred.
CONCLUSIONS
Drug-induced PS may be associated with dopamine-acetylcholine imbalance. This imbalance causes the dysfunction of the cortex and basal ganglia and the dysfunction of sensory and somatosensory system. Stopping the offending drugs is a choice for the treatment of PS. This is the first report of PS-induced brexpiprazole.
目的
本研究旨在报告 1 例伴有阿尔茨海默病的患者使用布瑞哌唑引起的 Pisa 综合征（PS），并讨论 PS 的发病机制和治疗方法。
方法
我们报告了 1 例 71 岁女性阿尔茨海默病患者。在服用布瑞哌唑 2 个月后，她出现了 PS。换用喹硫平后，症状得到改善；但出现短暂的急性肌张力障碍。
结论
药物引起的 PS 可能与多巴胺-乙酰胆碱失衡有关。这种失衡导致大脑皮层和基底节功能障碍以及感觉和躯体感觉系统功能障碍。停用引起不良反应的药物是治疗 PS 的一种选择。这是首例布瑞哌唑引起 PS 的报告。
Zotero 插件