Department of Ophthalmology and Visual Sciences, State University of New York, Upstate Medical University, Syracuse, NY.
Cornea. 2021 Mar 1;40(3):377-379. doi: 10.1097/ICO.0000000000002513.
To report a patient who presented with red eye and diffuse palpebral conjunctival thickening and papillary growth bilaterally.
A 63-year-old woman with a medical history of stage IV adenocarcinoma of the lung with metastasis to the bone, the lung, and the lymph nodes presented with redness and irritation of both eyes for 3 months. The patient has been treated with topical corticosteroids for 3 weeks with no relief of symptoms.
Clinical examination and pathology report of conjunctival biopsy confirmed the diagnosis of conjunctival acanthosis nigricans.
Conjunctival acanthosis nigricans is a rare paraneoplastic condition that resembles papilloma and can present a challenge in diagnosis. When acanthosis nigricans occurs after the diagnosis of malignancy, it can be an indicator of progression of the underlying condition. The diagnosis of conjunctival acanthosis nigricans in a patient with no history of cancer should prompt clinicians for further malignancy workup.
报告 1 例双侧眼红、弥漫性眼睑结膜增厚和乳头样生长的患者。
患者为 63 岁女性，患有 IV 期肺癌伴骨、肺和淋巴结转移，双眼发红伴刺激 3 个月。患者已接受 3 周的局部皮质类固醇治疗，但症状无缓解。
临床检查和结膜活检的病理报告证实了黑棘皮病性结膜炎的诊断。
黑棘皮病性结膜炎是一种罕见的副肿瘤性疾病，类似于乳头瘤，在诊断上具有挑战性。当恶性肿瘤诊断后出现黑棘皮病时，可能是潜在疾病进展的指标。对于无癌症病史的患者，如果出现黑棘皮病，应提示临床医生进一步进行恶性肿瘤检查。
