肝细胞癌患者的副肿瘤性黑棘皮病类型。
Paraneoplastic type of acanthosis nigricans in patient with hepatocellular carcinoma.
作者信息
Kamińska-Winciorek G, Brzezińska-Wcisło L, Lis-Swiety A, Krauze E
机构信息
Dermatological Department of Silesian University of Medicine, Katowice, Poland.
出版信息
Adv Med Sci. 2007;52:254-6.
UNLABELLED
Paraneoplastic acanthosis nigricans is connected with malignancies in adults in almost 100% of cases. The typical skin changes include: thickening and hyperpigmentation in typical localization with mucocutaneous involvement.
PURPOSE
The authors report a case of a malignant type of acanthosis nigricans in 42-year-old female patient with hepatocellular carcinoma.
CASE REPORT
First skin lesions appeared in 2000. The patient died within 22 months (of the first appearance of skin symptoms), because of hepatocellular carcinoma. Herein we report the clinical picture, skin involvement and diagnostic procedures in acanthosis nigricans.
CONCLUSIONS
Paraneoplastic type of acanthosis nigricans--in patient with hepatocellular carcinoma is not frequently reported in the literature. In the aspect of clinical occurrence of skin lesions suggesting acanthosis nigricans the diagnostics should be focused on internal malignancies.
未标注
副肿瘤性黑棘皮病在几乎100%的成年病例中与恶性肿瘤相关。典型的皮肤改变包括：典型部位增厚和色素沉着，并伴有黏膜皮肤受累。
目的
作者报告一例42岁患有肝细胞癌的女性患者发生恶性型黑棘皮病的病例。
病例报告
首例皮肤病变于2000年出现。患者在（皮肤症状首次出现后的）22个月内死于肝细胞癌。在此我们报告黑棘皮病的临床表现、皮肤受累情况及诊断程序。
结论
肝细胞癌患者并发副肿瘤性黑棘皮病在文献中报道较少。对于提示黑棘皮病的皮肤病变的临床发生情况，诊断应侧重于内部恶性肿瘤。
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