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评估高频波根管治疗在大鼠中的功能疗效。

Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats.

机构信息

Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, Osaka, Japan.

Unit of Dentistry, Osaka University Hospital, Suita, Osaka, Japan.

出版信息

PLoS One. 2020 Sep 29;15(9):e0239660. doi: 10.1371/journal.pone.0239660. eCollection 2020.

DOI:10.1371/journal.pone.0239660
PMID:32991601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7523981/
Abstract

The purpose of this study was to develop a high-frequency wave therapy model in rats and to investigate the influence of high-frequency waves on root canal treatment, which may provide a novel strategy for treating apical periodontitis. Root canal treatments with and without high-frequency wave irradiation were performed on the mandibular first molars of 10-week-old male Wistar rats. The mesial roots were evaluated radiologically, bacteriologically, and immunohistochemically. At 3 weeks after root canal treatment, lesion volume had decreased significantly more in the irradiated group than in the non-irradiated group, indicating successful development of the high-frequency therapy model. The use of high-frequency waves provided no additional bactericidal effect after root canal treatment. However, high-frequency wave irradiation was found to promote healing of periapical lesions on the host side through increased expression of fibroblast growth factor 2 and transforming growth factor-β1 and could therefore be useful as an adjuvant nonsurgical treatment for apical periodontitis.

摘要

本研究旨在建立大鼠高频波治疗模型，并探讨高频波对根管治疗的影响，以期为根尖周炎的治疗提供新策略。对 10 周龄雄性 Wistar 大鼠的下颌第一磨牙进行有高频波辐照和无高频波辐照的根管治疗，分别对近中根进行影像学、细菌学和免疫组织化学评估。在根管治疗后 3 周，辐照组的病变体积明显小于非辐照组，表明高频治疗模型成功建立。高频波的使用在根管治疗后并没有提供额外的杀菌效果。然而，研究发现，高频波辐照通过增加纤维母细胞生长因子 2 和转化生长因子-β1 的表达促进根尖病变的愈合，因此可作为根尖周炎的辅助非手术治疗手段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd71/7523981/1f391b1a1c74/pone.0239660.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd71/7523981/064b3c6ce1be/pone.0239660.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd71/7523981/b5081724c57d/pone.0239660.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd71/7523981/0315d7dd2e43/pone.0239660.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd71/7523981/1f391b1a1c74/pone.0239660.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd71/7523981/064b3c6ce1be/pone.0239660.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd71/7523981/b5081724c57d/pone.0239660.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd71/7523981/0315d7dd2e43/pone.0239660.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd71/7523981/1f391b1a1c74/pone.0239660.g004.jpg

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