Roberts A B, Baker J R
Obstet Gynecol. 1987 Aug;70(2):242-6.
We studied 30 diabetic pregnant women to compare serum fructosamine concentrations at different stages of gestation with fetal growth (as determined by ultrasonography) and with birth weight. Serum fructosamine levels in mothers of macrosomic infants were significantly higher (P less than .05) during the first trimester of pregnancy as compared with mothers of normal birth weight infants. Moreover, first-trimester fructosamine concentrations correlated significantly with birth weight (r = 0.68, P less than .001) and with ultrasound measurements of fetal abdominal circumference and femur length. The fetus destined to be macrosomic had an enlarged abdomen in the second trimester, often before 20 weeks' gestation. We conclude that maternal diabetic control during early gestation has an important influence on fetal growth and contributes to the development of fetal macrosomia.
我们研究了30名糖尿病孕妇，以比较妊娠不同阶段的血清果糖胺浓度与胎儿生长情况（通过超声检查确定）以及出生体重之间的关系。与正常出生体重婴儿的母亲相比，巨大儿母亲在妊娠早期血清果糖胺水平显著更高（P<0.05）。此外，妊娠早期的果糖胺浓度与出生体重（r = 0.68，P<0.001）以及胎儿腹围和股骨长度的超声测量值显著相关。注定为巨大儿的胎儿在妊娠中期腹部增大，通常在妊娠20周之前。我们得出结论，妊娠早期孕妇的糖尿病控制对胎儿生长有重要影响，并有助于胎儿巨大儿的发生。
