现实检验：了解CHK1的生物学特性和临床潜力。
Reality CHEK: Understanding the biology and clinical potential of CHK1.
作者信息
Neizer-Ashun Fiifi, Bhattacharya Resham
机构信息
Department of Cell Biology, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, United States.
Department of Cell Biology, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, United States; Department of Obstetrics and Gynecology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, United States; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, United States.
出版信息
Cancer Lett. 2021 Jan 28;497:202-211. doi: 10.1016/j.canlet.2020.09.016. Epub 2020 Sep 28.
The DNA damage response enables cells to cope with various stresses that threaten genomic integrity. A critical component of this response is the serine/threonine kinase CHK1 which is encoded by the CHEK1 gene. Originally identified as a regulator of the G2/M checkpoint, CHK1 has since been shown to play important roles in DNA replication, mitotic progression, DNA repair, and overall cell cycle regulation. However, the potential of CHK1 as a cancer therapy has not been realized clinically. Herein we expound our current understanding of the principal roles of CHK1 and highlight different avenues for CHK1 targeting in cancer therapy.
DNA损伤反应使细胞能够应对各种威胁基因组完整性的应激。这种反应的一个关键组成部分是丝氨酸/苏氨酸激酶CHK1，它由CHEK1基因编码。CHK1最初被鉴定为G2/M期检查点的调节因子，后来被证明在DNA复制、有丝分裂进程、DNA修复和整体细胞周期调控中发挥重要作用。然而，CHK1作为癌症治疗靶点的潜力尚未在临床上得到实现。在此，我们阐述了目前对CHK1主要作用的理解，并强调了在癌症治疗中靶向CHK1的不同途径。
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