Petrocheilou Argyri, Kaditis Athanasios G, Troupi Evgenia, Loukou Ioanna
Cystic Fibrosis Department, Agia Sofia Children's Hospital, Thivon and Papadiamantopoulou, 115 27 Athens, Greece.
Division of Pediatric Pulmonology, First Department of Pediatrics, National and Kapodistrian University of Athens School of Medicine and Agia Sofia Children's Hospital, Thivon and Papadiamantopoulou, 115 27 Athens, Greece.
Children (Basel). 2020 Sep 27;7(10):153. doi: 10.3390/children7100153.
Nebulizers are used by the great majority of cystic fibrosis patients for delivery of cornerstone treatments. Inhalation technique and adequate disinfection and maintenance are important for optimizing medication delivery. In this study, inhalation technique and nebulizer disinfection/maintenance were assessed in cystic fibrosis patients by direct observation in clinic and completion of a scoring sheet. A total of 108 patients were recruited. The maximum inhalation technique score was attained by 30.5% and adequate inhalation technique score by 74.08% of patients. The inhalation technique score was best with the vibrating mesh nebulizer ( = 0.038), while patient age and number of nebulized medications did not affect ITS significantly ( > 0.05). Nebulizer disinfection/maintenance score was excellent in only 31.48%. Most families kept the nebulizer clean and used appropriate disinfection method, but only half of them replaced the nebulizer and nebulizer cup at the recommended time intervals. Nebulizer disinfection/maintenance score was positively affected by a number of nebulized medications and negatively by years of equipment use ( = 0.009 and = 0.001, respectively). Even though inhalation technique and disinfection/maintenance practices were found to be adequate in a large proportion of cases, there is still a need for regular review and education. The type of nebulizer was associated with improved inhalation technique, but more data are required before making specific recommendations.
绝大多数囊性纤维化患者使用雾化器来进行基础治疗。吸入技术以及充分的消毒和维护对于优化药物输送非常重要。在本研究中,通过在诊所直接观察和填写评分表,对囊性纤维化患者的吸入技术以及雾化器消毒/维护情况进行了评估。共招募了108名患者。30.5%的患者达到了最大吸入技术评分,74.08%的患者达到了充分吸入技术评分。振动网式雾化器的吸入技术评分最佳( = 0.038),而患者年龄和雾化药物数量对吸入技术评分无显著影响( > 0.05)。雾化器消毒/维护评分仅有31.48%为优秀。大多数家庭保持雾化器清洁并采用了适当的消毒方法,但只有一半的家庭按照推荐的时间间隔更换雾化器和雾化杯。雾化器消毒/维护评分受到雾化药物数量的正向影响以及设备使用年限的负向影响(分别为 = 0.009和 = 0.001)。尽管在大部分情况下吸入技术和消毒/维护措施被认为是充分的,但仍需要定期复查和教育。雾化器的类型与吸入技术的改善有关,但在提出具体建议之前还需要更多数据。