内皮细胞对2019冠状病毒病的影响。
Endothelial Cell Contributions to COVID-19.
作者信息
Oxford Alexandra E, Halla Fabio, Robertson Evan B, Morrison Brad E
机构信息
Department of Biological Sciences, Boise State University, Boise, ID 83725, USA.
Biomolecular Ph.D. Program, Boise State University, Boise, ID 83725, USA.
出版信息
Pathogens. 2020 Sep 25;9(10):785. doi: 10.3390/pathogens9100785.
Understanding of the clinical, histological and molecular features of the novel coronavirus 2019 (Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)) has remained elusive. Coronavirus disease 2019 (COVID-19) caused by this virus has unusual clinical presentation with regard to other related coronaviruses. Recent reports suggest that SARS-CoV-2, unlike other related viruses, infects and replicates within endothelial cells, which may explain a significant portion of the observed clinical pathology. Likewise, mounting evidence associates vascular and endothelial cell dysfunction with increased mortality. This review focuses on understanding how endothelial cell pathology is caused by SARS-CoV-2 at the molecular and cellular levels and how these events relate to COVID-19. A detailed examination of current knowledge regarding canonical inflammatory reaction pathways as well as alteration of endothelial cell-derived exosomes and transdifferentiation by SARS-CoV-2 is included in this assessment. Additionally, given an understanding of endothelial contributions to COVID-19, potential therapeutic aims are discussed, particularly as would affect endothelial function and pathology.
对2019新型冠状病毒（严重急性呼吸综合征冠状病毒2，即SARS-CoV-2）的临床、组织学和分子特征的了解仍然有限。由这种病毒引起的2019冠状病毒病（COVID-19）在临床表现上与其他相关冠状病毒有所不同。最近的报告表明，与其他相关病毒不同，SARS-CoV-2在内皮细胞内感染并复制，这可能解释了观察到的临床病理学的很大一部分原因。同样，越来越多的证据表明血管和内皮细胞功能障碍与死亡率增加有关。本综述着重于了解SARS-CoV-2如何在分子和细胞水平上导致内皮细胞病变，以及这些事件与COVID-19的关系。本评估包括对当前关于经典炎症反应途径的知识以及SARS-CoV-2对内皮细胞衍生外泌体和转分化的改变的详细研究。此外，鉴于了解内皮细胞对COVID-19的影响，讨论了潜在的治疗目标，特别是那些会影响内皮功能和病理的目标。
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