Microbiology and Immunology Department, University of Texas Medical Branch, Galveston, TX 77555, USA.
Biochemistry and Molecular Biology Department, University of Texas Medical Branch, Galveston, TX 77555, USA.
Viruses. 2020 Sep 25;12(10):1082. doi: 10.3390/v12101082.
Flaviviruses are significant human pathogens that cause frequent emerging and reemerging epidemics around the world. Better molecular tools for studying, diagnosing, and treating these diseases are needed. Reporter viruses represent potent tools to fill this gap but have been hindered by genetic instability. Recent advances have overcome these hurdles, opening the way for increased use of stable reporter flaviviruses to diagnose infections, screen and study antiviral compounds, and serve as potential vaccine vectors.
黄病毒是重要的人类病原体，在全球范围内引起频繁的新发和再发传染病。需要更好的分子工具来研究、诊断和治疗这些疾病。报告病毒是填补这一空白的有力工具，但由于遗传不稳定性而受到阻碍。最近的进展克服了这些障碍，为增加使用稳定的报告黄病毒来诊断感染、筛选和研究抗病毒化合物以及作为潜在疫苗载体铺平了道路。
