豚鼠组织对内毒素的过敏反应：与内毒素毒性的关系。
Anaphylactic reactions to endotoxin in guinea-pig tissues: relationship to endotoxin toxicity.
作者信息
McLean A J
出版信息
Br J Pharmacol. 1977 Jul;60(3):369-73. doi: 10.1111/j.1476-5381.1977.tb07510.x.
1 A lipopolysaccharide extract of Escherichia coli 026:B6 cells (026:B6(B) endotoxin) was shown to be toxic to normal adult guinea-pigs. 2 The agent had no action on isolated preparations of ileum and heart taken from normal adult guinea-pigs. 3 Ileal segments from animals actively immunized against 026:B6(B) endotoxin showed dose-dependent contractions when exposed to endotoxin. Desensitization phenomena were demonstrated. 4 Reactivity of 026:B6(B) endotoxin was transferred to isolated preparations of ileum and heart from normal animals by passive transfer of immune serum. 5 Tissue responses to 026:B6(B) were associated with release of ileal spasmogen into the bath medium. Mepyramine blocked the effects of this spasmogen at bath concentrations which caused little change in ileal responses to carbachol. 6 It is concluded that E. coli endotoxin can elicit anaphylactic reactions, and that this process may potentiate endotoxin toxicity in sensitized animals. However, endotoxin toxicity in guinea-pigs does not appear to depend on this kind of allergic process.
- 大肠杆菌026:B6细胞的脂多糖提取物（026:B6(B)内毒素）对正常成年豚鼠具有毒性。2. 该制剂对取自正常成年豚鼠的回肠和心脏的离体标本无作用。3. 主动免疫026:B6(B)内毒素的动物的回肠段在暴露于内毒素时呈现剂量依赖性收缩。脱敏现象得到证实。4. 通过免疫血清的被动转移，026:B6(B)内毒素的反应性被转移到正常动物的回肠和心脏的离体标本上。5. 组织对026:B6(B)的反应与回肠痉挛原释放到浴液介质中有关。在浴液浓度下，美吡拉敏阻断了这种痉挛原的作用，而该浓度对回肠对卡巴胆碱的反应几乎没有影响。6. 得出的结论是，大肠杆菌内毒素可引发过敏反应，并且这一过程可能会增强致敏动物体内内毒素的毒性。然而，豚鼠体内的内毒素毒性似乎并不取决于这种过敏过程。
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