Khasraghi Samaneh Salkhi, Shojaei Akbar, Sundararaj Uttandaraman
Department of Chemical and Petroleum Engineering, Sharif University of Technology, P.O. Box 11155-9465, Tehran, Iran; Department of Chemical and Petroleum Engineering, University of Calgary, Calgary, Canada.
Department of Chemical and Petroleum Engineering, Sharif University of Technology, P.O. Box 11155-9465, Tehran, Iran.
Mater Sci Eng C Mater Biol Appl. 2020 Sep;114:110993. doi: 10.1016/j.msec.2020.110993. Epub 2020 May 6.
The multifunctional nanostructures with superparamagnetic and luminescent properties undergo revolution in the field of bio-nanotechnology. In this article, we reported a facile and efficient one-step modified co-precipitation method to load superparamagnetic FeO nanoparticle on oxidized nanodiamond (Ox-ND). Subsequently, the as-prepared Ox-ND/FeO hybrid nanoparticle was surface functionalized with vinyltrimethoxysilane (VTMS) to enhance its compatibility with organic media. The structure, morphology, magnetic, and optical properties of the nanohybrid were systematically investigated. The results confirmed successful loading of crystalline FeO on the surface of Ox-ND. Ox-ND/FeO multifunctional hybrid nanoparticle presented strong superparamagnetism (with a saturation magnetization of 67 emu/g at room temperature) and photoluminescence (blue emission) with good chemical reactivity. PrestoBlue assay indicated great biocompatibility of silanized Ox-ND/FeO in MCF-7 cells even at high concentrations, e.g. 7.2 mg/mL. The hybrid nanoparticle synthesized in this study potentially opens doors for high contrast imaging and targeted delivery applications.
具有超顺磁性和发光特性的多功能纳米结构在生物纳米技术领域引发了变革。在本文中，我们报道了一种简便高效的一步改性共沉淀法，用于将超顺磁性FeO纳米颗粒负载到氧化纳米金刚石（Ox-ND）上。随后，用乙烯基三甲氧基硅烷（VTMS）对所制备的Ox-ND/FeO杂化纳米颗粒进行表面功能化，以增强其与有机介质的相容性。对该纳米杂化物的结构、形态、磁性和光学性质进行了系统研究。结果证实了晶体FeO成功负载在Ox-ND表面。Ox-ND/FeO多功能杂化纳米颗粒表现出强超顺磁性（室温下饱和磁化强度为67 emu/g）和具有良好化学反应性的光致发光（蓝色发射）。PrestoBlue检测表明，即使在高浓度（例如7.2 mg/mL）下，硅烷化的Ox-ND/FeO在MCF-7细胞中也具有良好的生物相容性。本研究中合成的杂化纳米颗粒可能为高对比度成像和靶向递送应用打开大门。
