Klujszo Elzbieta H, Parcheta Piotr, Witkowska Anna B, Krecisz Beata
Department of Dermatology, Regional Hospital, Kielce, Poland.
Graduate of Medical University, Szeged, Hungary.
Postepy Dermatol Alergol. 2020 Aug;37(4):468-474. doi: 10.5114/ada.2019.83983. Epub 2019 Jul 25.
Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the western countries. Psoriatic patients are at higher risk of having NAFLD, and at higher risk of experiencing a more severe form of the disease with poorer outcomes. The components of the metabolic syndrome - obesity, lipid abnormalities, hypertension, and type 2 diabetes - significantly correlate with NAFLD progression. The inflammatory state present in psoriasis plays a significant role in development of NAFLD and the metabolic syndrome. All patients with psoriasis and insulin resistance and risk factors for metabolic syndrome should also been screened for NAFLD, and planning of the treatment options should always take into consideration the possible risks related to the liver, especially in patients with NAFLD.
非酒精性脂肪性肝病（NAFLD）是西方国家最常见的肝脏病变。银屑病患者患NAFLD的风险更高，且患更严重形式疾病及预后较差的风险也更高。代谢综合征的组成部分——肥胖、血脂异常、高血压和2型糖尿病——与NAFLD的进展显著相关。银屑病中存在的炎症状态在NAFLD和代谢综合征的发展中起重要作用。所有患有银屑病且有胰岛素抵抗和代谢综合征风险因素的患者也应筛查NAFLD，治疗方案的规划应始终考虑到与肝脏相关的可能风险，尤其是在患有NAFLD的患者中。
