Mustata Maria-Lorena, Neagoe Carmen-Daniela, Ionescu Mihaela, Predoi Maria-Cristina, Mitran Ana-Maria, Ianosi Simona-Laura
Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Diagnostics (Basel). 2024 Aug 14;14(16):1774. doi: 10.3390/diagnostics14161774.
Psoriasis is an increasingly common chronic immune-mediated skin disease recognized for its systemic effects that extend beyond the skin and include various cardiovascular diseases, neurological diseases, type 2 diabetes, and metabolic syndrome. This study aimed to explore the complex relationship between psoriasis and metabolic syndrome by analyzing clinical, biochemical, and immunological parameters in patients with psoriasis alone and in patients combining psoriasis and metabolic syndrome. A total of 150 patients were enrolled, 76 with psoriasis only (PSO) and 74 with psoriasis and metabolic syndrome (PSO-MS). Data collected included anthropometric measurements, blood tests, and inflammatory markers. Statistical analysis was performed using the independent -test, Mann-Whitney U test, Kruskal-Wallis test, and chi-square test to compare the two groups. Patients in the PSO-MS group had a significantly higher body weight, abdominal circumference, BMI, and inflammatory markers compared to patients with PSO. In addition, increased levels of IL-17A, cholesterol, triglycerides, and glucose were observed in the PSO-MS group. This study highlights the increased metabolic risk and exacerbated systemic inflammation associated with the coexistence of psoriasis and metabolic syndrome. These findings demonstrate the need for a comprehensive therapeutic approach and early intervention to manage metabolic complications in patients with psoriasis and metabolic syndrome.
银屑病是一种日益常见的慢性免疫介导性皮肤病，因其全身性影响而被认可，这种影响不仅限于皮肤，还包括各种心血管疾病、神经疾病、2型糖尿病和代谢综合征。本研究旨在通过分析仅患有银屑病的患者以及合并银屑病和代谢综合征的患者的临床、生化和免疫参数，探讨银屑病与代谢综合征之间的复杂关系。总共招募了150名患者，其中76名仅患有银屑病（PSO），74名患有银屑病和代谢综合征（PSO-MS）。收集的数据包括人体测量、血液检测和炎症标志物。使用独立样本t检验、曼-惠特尼U检验、克鲁斯卡尔-沃利斯检验和卡方检验进行统计分析，以比较两组。与PSO患者相比，PSO-MS组患者的体重、腹围、BMI和炎症标志物显著更高。此外，PSO-MS组中观察到IL-17A、胆固醇、甘油三酯和葡萄糖水平升高。本研究强调了银屑病和代谢综合征共存时代谢风险增加以及全身炎症加剧。这些发现表明需要一种全面的治疗方法和早期干预，以管理银屑病和代谢综合征患者的代谢并发症。
