Zhang Yu, Lin Chengzhong, Wang Xu, Ji Tong
Department of Oral and Maxillofacial Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.
Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.
Oncol Lett. 2020 Nov;20(5):253. doi: 10.3892/ol.2020.12116. Epub 2020 Sep 18.
Nerves have been widely demonstrated to exert major effects in tumor-associated microenvironments. Due to the characteristic innervation of the oral cavity and the fact that cancer-associated pain is a distinct feature of oral squamous cell carcinoma (OSCC), the sensory nerves may dominate in the OSCC-nerve microenvironment. As the most abundant neuropeptide in the trigeminal ganglion, the calcitonin gene-related peptide (CGRP) exerts a dual effect on cancer development and cancer-associated pain in various types of cancer. The present review explored the potential molecular mechanisms of the roles of CGRP in cancer development and cancer-associated pain, suggesting that CGRP may be a promising therapeutic target for OSCC.
神经已被广泛证明在肿瘤相关微环境中发挥主要作用。由于口腔的独特神经支配以及癌症相关疼痛是口腔鳞状细胞癌（OSCC）的一个显著特征，感觉神经可能在OSCC-神经微环境中占主导地位。作为三叉神经节中最丰富的神经肽，降钙素基因相关肽（CGRP）在各种类型的癌症中对癌症发展和癌症相关疼痛发挥双重作用。本综述探讨了CGRP在癌症发展和癌症相关疼痛中作用的潜在分子机制，表明CGRP可能是OSCC的一个有前景的治疗靶点。
