Suner Aslı, Carr Brian I
Ann Med Surg (Lond). 2020 Sep 6;58:167-171. doi: 10.1016/j.amsu.2020.08.042. eCollection 2020 Oct.
Inflammation is a recognized concomitant of hepatocellular carcinoma (HCC) and its indices are prognostically useful.
To evaluate two commonly used inflammatory indices, neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), to examine their relationship to maximum tumor diameter (MTD) and to survival.
A database of 1024 prospectively-accrued HCC patients was examined, who had full baseline tumor parameter data, including CT scan information on HCC size and whose survival was known. Analyses of NLR and PLR were correlated to MDT and to survival. NLR and PLR cutoffs were calculated from receiver operator characteristic curves.
Every MTD pair had significantly different PLR values, for MTD groups of groups <2/≥2, <3/≥3, <4/≥4, <5/≥5 cm. However there were few significant differences in NLR values. Logistic regression models of different MTD groups likewise showed significance for PLR. Patients with both low NLR and low PLR had the longest overall survival compared to all the other 3 combinations of NLR and PLR. In a Cox regression analysis, univariate models on NLR (≤3.02/>3.02) and PLR (≤6.82/>6.82) groups, showed significance for PLR, p = 0.034 and approaching significance for NLR, p = 0.057.
MTD pairs down to <2/≥2 cm showed significance for PLR, survival showed significance for PLR and almost for NLR.
炎症是肝细胞癌（HCC）公认的伴随症状，其指标具有预后价值。
评估两种常用的炎症指标，即中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR），以研究它们与最大肿瘤直径（MTD）及生存率的关系。
对一个包含1024例前瞻性纳入的HCC患者的数据库进行研究，这些患者拥有完整的基线肿瘤参数数据，包括关于HCC大小的CT扫描信息且其生存情况已知。对NLR和PLR进行分析，并与MTD及生存率进行相关性研究。通过受试者工作特征曲线计算NLR和PLR的临界值。
对于MTD分组为<2/≥2 cm、<3/≥3 cm、<4/≥4 cm、<5/≥5 cm的各组，每一对MTD对应的PLR值均存在显著差异。然而，NLR值的显著差异较少。不同MTD组的逻辑回归模型同样显示PLR具有显著性。与NLR和PLR的其他3种组合相比，NLR和PLR均低的患者总生存期最长。在Cox回归分析中，NLR（≤3.02/>3.02）和PLR（≤6.82/>6.82）分组的单变量模型显示PLR具有显著性，p = 0.034，NLR接近显著性，p = 0.057。
低至<2/≥2 cm的MTD对PLR具有显著性，生存率对PLR具有显著性，对NLR几乎也具有显著性。
