斯里兰卡双胞胎登记生物样本库：南亚首个双胞胎生物样本库。
The Sri Lankan twin registry biobank: South Asia's first twin biobank.
机构信息
Institute for Research and Development in Health and Social Care, Colombo, Sri Lanka.
Department of Medicine, University of Rajarata, Mihintale, Sri Lanka.
出版信息
Glob Health Epidemiol Genom. 2020 Sep 9;5:e5. doi: 10.1017/gheg.2020.4. eCollection 2020.
INTRODUCTION
Biobanks are a valuable resource for creating advancements in science through cutting-edge omics research. Twin research methods allow us to understand the degree to which genetics and environmental factors contribute to health outcomes.
METHODS
The Sri Lankan Twin Registry biobank (SLTR-b) was established in 2015 as part of Colombo Twin and Singleton Follow-up Study. Venous blood and urine were collected from twins and comparative sample of singletons for clinical investigations and biobanking.
RESULTS
The SLTR-b currently houses 3369 DNA and serum samples. Biobank specimens are linked to longitudinal questionnaire data, clinical investigations, anthropometric measurements, and other data.
DISCUSSION
The SLTR-b aims to address gaps in health and genetics research. It will provide opportunities for academic collaborations, local and international, and capacity building of future research leaders in twin and omics research. This paper provides a cohort profile of the SLTR-b and its linked data, and an overview of the strategies used for biobanking.
简介
生物银行是通过前沿组学研究推动科学进步的宝贵资源。双胞胎研究方法使我们能够了解遗传和环境因素对健康结果的影响程度。
方法
斯里兰卡双胞胎登记生物银行（SLTR-b）于 2015 年作为科伦坡双胞胎和单胎随访研究的一部分成立。采集双胞胎和单胎的静脉血和尿液进行临床研究和生物样本库。
结果
SLTR-b 目前拥有 3369 份 DNA 和血清样本。生物样本库标本与纵向问卷调查数据、临床研究、人体测量数据和其他数据相关联。
讨论
SLTR-b 旨在解决健康和遗传学研究中的差距。它将为学术合作提供机会，包括本地和国际合作，以及为双胞胎和组学研究的未来研究领导者提供能力建设。本文提供了 SLTR-b 的队列概况及其关联数据，并概述了生物样本库的策略。
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