Department of Stomatology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Endodontics, Southern Medical University Hospital of Stomatology (Guandong Stomatology Hospital), Guangzhou, China.
J Periodontol. 2021 Jun;92(6):833-843. doi: 10.1002/JPER.20-0269. Epub 2020 Oct 27.
This study examines the association of periodontitis with telomere length (TL) and effect modification by population characteristics.
We analyzed data from 3,478 participants from the 1999 to 2002 National Health and Nutrition Examination Survey. Probing depth, attachment loss, and bleed on probing (BOP, available for 1,973 participants only) were examined on the distal, mesial, or mid-facial site of each tooth in two randomly selected quadrants. We defined periodontitis severity according to the Centers for Disease Control/American Academy of Periodontology guideline. TL from leukocytes was measured with qPCR. We used linear and logistic regression to examine the adjusted association of different severity of periodontitis and BOP with continuous TL (bp) and dichotomized short TL (<median), respectively. To assess effect modification, we stratified the analyses by a priori selected population characteristics including sex, age, body weight status, smoking, and cardiometabolic comorbidity.
Moderate BOP (<10% bleeding sites) was significantly associated with a shorter continuous TL (β = -89.0, SE = 37.8). Moderate to severe periodontitis was significantly associated with 47% (95% confidence interval [IL], 1.04 to 2.09) higher odds of shorter TL, compared with those with mild or no periodontitis. The association was stronger in those who were female (adjusted OR, 1.76; 95% CI, 1.10 to 2.83), overweight or obese (adjusted OR, 1.64; 95% CI, 1.12 to 2.41), or had cardiometabolic comorbidities (adjusted OR, 2.13; 95% CI, 1.38 to 3.29).
Periodontitis was associated with TL, a biomarker of cellular aging. The association was stronger in females, overweight or obese, or those with cardiometabolic diseases. Treatment on periodontitis could potentially protect individuals from aging-related diseases.
本研究探讨了牙周炎与端粒长度（TL）的关联以及人群特征的影响修饰。
我们分析了来自 1999 年至 2002 年全国健康与营养调查的 3478 名参与者的数据。在每颗牙齿的两个随机选择的象限的远中、近中和中面部位点上检查探测深度、附着丧失和探诊出血（仅在 1973 名参与者中可用）。我们根据疾病控制与预防中心/美国牙周病学会指南定义了牙周炎的严重程度。使用 qPCR 测量白细胞中的 TL。我们使用线性和逻辑回归分别检查不同严重程度的牙周炎和 BOP 与连续 TL（bp）和二分类短 TL（<中位数）的调整关联。为了评估效应修饰，我们根据性别、年龄、体重状况、吸烟和心血管代谢合并症等预先选择的人群特征对分析进行分层。
中度 BOP（<10%出血部位）与连续 TL 缩短显著相关（β=-89.0，SE=37.8）。与轻度或无牙周炎相比，中重度牙周炎与较短 TL 的几率增加 47%（95%置信区间[IL]，1.04 至 2.09）显著相关。这种关联在女性（调整后的 OR，1.76；95%CI，1.10 至 2.83）、超重或肥胖（调整后的 OR，1.64；95%CI，1.12 至 2.41）或患有心血管代谢合并症的人群中更强（调整后的 OR，2.13；95%CI，1.38 至 3.29）。
牙周炎与 TL 相关，TL 是细胞衰老的生物标志物。这种关联在女性、超重或肥胖或患有心血管代谢疾病的人群中更强。牙周炎的治疗可能会潜在地保护个体免受与衰老相关的疾病的影响。
