The First Affiliated Hospital of Zhengzhou University, 450000, PR China.
Academy of Medical Science, Zhengzhou University, 450000, PR China.
Future Oncol. 2021 Jan;17(3):301-313. doi: 10.2217/fon-2020-0022. Epub 2020 Sep 30.
Screening and therapeutic programs for colorectal cancer (CRC) are invasive or not effective and unable to meet patient needs. Major advances in immunogenomics may change this status but need more exploration. Differentially expressed genes and immune-related genes (IRGs) were identified by computational methods. A prognostic model was established and validated based on survival-related IRGs via stepwise multivariate Cox regression analysis. Nine IRGs were selected and identified as survival-related genes. A 7-gene prognostic model could offer a preliminary and valid determination of risk in CRC patients. The area under the curve of the receiver operating characteristic was 0.672. The 7-gene prognostic model might be used as a novel prognostic tool in CRC patients.
结直肠癌（CRC）的筛查和治疗方案具有侵袭性或效果不佳，无法满足患者的需求。免疫基因组学的重大进展可能会改变这种状况，但需要进一步探索。通过计算方法鉴定差异表达基因和免疫相关基因（IRGs）。通过逐步多变量 Cox 回归分析，基于与生存相关的 IRGs 建立和验证预后模型。选择并鉴定了 9 个 IRGs 作为与生存相关的基因。7 基因预后模型可初步、有效地确定 CRC 患者的风险。受试者工作特征曲线下面积为 0.672。7 基因预后模型可作为 CRC 患者的一种新的预后工具。
