8-氨基喹啉作为双齿无痕迹导向基团用于铜催化的 -carboranes 的选择性 B(4,5)-H 二硫代磺酰化反应。
8-Aminoquinoline as a bidentate traceless directing group for Cu-catalyzed selective B(4,5)-H disulfenylation of -carboranes.
机构信息
Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
出版信息
Chem Commun (Camb). 2020 Oct 27;56(85):12997-13000. doi: 10.1039/d0cc05207h.
A traceless bidentate directing group guided copper catalyzed direct cage B(4,5)-H disulfenylation of o-carboranes has been achieved, leading to a series of B(4,5)-disulfenylated o-carborane derivatives in high yields with excellent regioselectivity. The in situ departure of the 8-aminoquinoline bidentate auxiliary circumvents additional processes for directing group removal, thus enhancing the atom-/step-economy.
一种无痕双齿导向基团引导的铜催化直接笼 B(4,5)-H 二硫代化 o-卡硼烷已被实现，导致一系列 B(4,5)-二硫代化 o-卡硼烷衍生物以高产率和优异的区域选择性得到。8-氨基喹啉双齿辅助基团的原位离去避免了导向基团去除的额外步骤，从而提高了原子/步骤经济性。
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