铱催化的硫叶立德对 - 碳硼烷的选择性B(4)-H酰甲基化反应
Iridium-Catalyzed Selective B(4)-H Acylmethylation of -Carboranes with Sulfoxonium Ylides.
作者信息
Zhang Lin-Bao, Xie Zuowei
机构信息
Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong 999077, China.
State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042, China.
出版信息
Org Lett. 2022 Feb 18;24(6):1318-1322. doi: 10.1021/acs.orglett.1c04335. Epub 2022 Feb 7.
A highly efficient Ir-catalyzed regioselective cage B(4)-H acylmethylation of -carboranyl acids using sulfoxonium ylides as alkylating regents has been developed, leading to the preparation of a large class of B(4)-acylmethylated -carboranes in good to excellent yields with a broad substrate scope under redox neutral conditions. The -COOH moiety serves as the traceless directing group and controls the regioselectivity and monoselectivity.
已开发出一种高效的铱催化的区域选择性笼状B(4)-H酰甲基化反应，该反应使用氧化锍叶立德作为烷基化试剂，可在氧化还原中性条件下以良好至优异的产率制备一大类B(4)-酰甲基化的碳硼烷，底物范围广泛。-COOH部分作为无痕导向基团，控制区域选择性和单选择性。
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