Emmert S, van Welzen A, Masur K, Gerling T, Bekeschus S, Eschenburg C, Wahl P, Bernhardt T, Schäfer M, Semmler M L, Grabow N, Fischer T, Thiem A, Jung O, Boeckmann L
Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsmedizin Rostock, Strempelstr. 13, 18057, Rostock, Deutschland.
ZIK plasmatis, Leibniz Institut für Plasmaforschung und Technologie e. V. (INP), Greifswald, Deutschland.
Hautarzt. 2020 Nov;71(11):855-862. doi: 10.1007/s00105-020-04696-y.
Besides acute wounds (through trauma or surgical interventions), chronic wounds comprise a relatively large and heterogeneous group of diseases. These include leg ulcers with venous disease greatly prevailing arterial disease, diabetic foot syndrome, and pressure ulcers. Due to a considerable treatment resistance against such therapies, new and effective, additive treatment options especially for chronic wounds are needed. Wound treatment with cold atmospheric plasma (CAP) constitutes such an innovative option.
Current research regarding the efficacy of cold plasma for healing of acute and chronic wounds is summarized.
The literature on CAP applications in wound healing has been screened and reviewed.
With CAP, several effects that promote wound healing can be simultaneously applied in one application. On the one hand, CAP exerts a strong and broad antimicrobial activity against biofilm. On the other hand, the plasma cocktail, which consists of reactive nitrogen and oxygen species, UV, and charged particles (electrical current), mediates tissue-stimulating, blood flow-promoting, and anti-inflammatory effects. Marked germ reduction on wounds and accelerated wound healing have already been convincingly demonstrated in controlled clinical studies.
The comprehensive CAP study landscape with structured case report summaries and randomized case-control studies allows the conclusion that CAP is safe, effective, and easy to handle for wound treatment. The utilization of CAP in addition to standard wound treatments is starting to enter routine clinical practice.
除急性伤口（因创伤或手术干预所致）外，慢性伤口构成了一组相对庞大且异质性的疾病。这些疾病包括静脉疾病为主导、动脉疾病较少见的腿部溃疡、糖尿病足综合征和压疮。由于对此类疗法存在相当大的治疗抵抗性，尤其对于慢性伤口，需要新的、有效的辅助治疗选择。冷大气等离子体（CAP）伤口治疗即构成这样一种创新选择。
总结当前关于冷等离子体对急性和慢性伤口愈合疗效的研究。
筛选并综述了关于CAP在伤口愈合中应用的文献。
使用CAP时，一次应用可同时产生多种促进伤口愈合的效果。一方面，CAP对生物膜具有强大且广泛的抗菌活性。另一方面，由活性氮和氧物种、紫外线及带电粒子（电流）组成的等离子体混合物可介导组织刺激、促进血流和抗炎作用。在对照临床研究中已令人信服地证明了伤口上细菌的显著减少及伤口愈合加速。
具有结构化病例报告摘要和随机病例对照研究的全面CAP研究格局表明，CAP用于伤口治疗是安全、有效且易于操作的。除标准伤口治疗外，CAP的应用正开始进入常规临床实践。
