Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Department of Physiology, McGill University, Montreal, Quebec, Canada.
J Neurophysiol. 2020 Nov 1;124(5):1312-1314. doi: 10.1152/jn.00472.2020. Epub 2020 Sep 30.
Optogenetics has become a popular tool to probe the link between neural circuits and behavior, since the technique was first introduced in 2005. Recently, Gong et al. (Gong X, Mendoza-Halliday D, Ting JT, Kaiser T, Sun X, Bastos AM, Wimmer RD, Guo B, Chen Q, Zhou Y, Pruner M, Wu CWH, Park D, Deisseroth K, Barak B, Boyden ES, Miller EK, Halassa MM, Fu Z, Bi G, Desimone R, Feng G. Neuron 107: 38-51, 2020) developed an ultra-sensitive step-function opsin capable of activating any region of the mouse brain and cortical areas in macaques with external illumination, thus aiming toward minimally invasive light delivery. In this article, we highlight and discuss the new opsin's potential in nonhuman primate research.
光遗传学已成为探究神经回路与行为之间关系的一种流行工具，该技术于 2005 年首次被引入。最近，宫等人（Gong X，Mendoza-Halliday D，Ting JT，Kaiser T，Sun X，Bastos AM，Wimmer RD，Guo B，Chen Q，Zhou Y，Pruner M，Wu CWH，Park D，Deisseroth K，Barak B，Boyden ES，Miller EK，Halassa MM，Fu Z，Bi G，Desimone R，Feng G. Neuron 107: 38-51, 2020）开发了一种超灵敏的阶跃式光感受器，能够在外部光照下激活小鼠大脑的任何区域和猕猴的皮质区域，从而实现微创的光传递。在本文中，我们重点讨论了这种新光感受器在非人类灵长类动物研究中的应用潜力。
