School of Physical Education and Sport of Ribeirão Preto, University of São Paulo at Ribeirão Preto, Ribeirão Preto, SP, Brazil.
Ribeirão Preto Faculty of Philosophy, Sciences and Letters, University of São Paulo at Ribeirão Preto, Ribeirão Preto, SP, Brazil.
PLoS One. 2020 Sep 30;15(9):e0238044. doi: 10.1371/journal.pone.0238044. eCollection 2020.
Studies report that intense physical activity influences the down-regulation of immune function in athletes as well as the interaction between adipose tissue and the immune system.
This study aimed to compare the plasma soluble levels of the immune checkpoint HLA-G (sHLA-G) molecule with the fat mass and muscle mass index among 77 bodybuilders and 64 controls.
The comparisons of the percentage of body fat (%BF) revealed that the groups of male and female bodybuilders showed a statistically significant reduction in the percentage of body fat when compared to their control group, (P <0.0001, for both comparisons). Regarding sHLA-G levels, the comparisons showed that the group of male bodybuilders had significantly higher sHLA-G levels compared to the group of female bodybuilders (P = 0.0011).
Our results showed that in bodybuilders with less body fat, the systemic levels of soluble HLA-G, an immunological molecule with recognized immunosuppressive function, are significantly higher and suggest that this immune mechanism may corroborate the immunosuppressive state in athletes undergoing intense and prolonged physical training.
研究报告表明，剧烈的身体活动会影响运动员的免疫功能下调以及脂肪组织和免疫系统之间的相互作用。
本研究旨在比较 77 名健美运动员和 64 名对照组之间免疫检查点 HLA-G（sHLA-G）分子的血浆可溶性水平与脂肪量和肌肉量指数。
对体脂百分比（%BF）的比较表明，男性和女性健美运动员组与对照组相比，体脂百分比有统计学显著降低（P<0.0001，两次比较均如此）。关于 sHLA-G 水平，比较显示男性健美运动员组的 sHLA-G 水平明显高于女性健美运动员组（P=0.0011）。
我们的结果表明，在体脂较少的健美运动员中，可溶性 HLA-G 的全身水平（一种具有公认免疫抑制功能的免疫分子）显著升高，这表明这种免疫机制可能支持进行剧烈和长期身体训练的运动员的免疫抑制状态。
