Biomarker Discovery, Genentech, South San Francisco, CA
Department of Immunology, Genentech, South San Francisco, CA
J Exp Med. 2020 Feb 13;217(3):e20192195. doi: 10.1084/jem.20192195. Print 2020 Mar 2.
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. In this review, we focus specifically on the role of IL-22 in the intestinal epithelium. We summarize recent advances in our understanding of how IL-22 regulates homeostasis and host defense, and we discuss the IL-22 pathway as a therapeutic target in diseases of the intestine, including inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and cancer.
细胞因子白细胞介素-22（IL-22）是上皮细胞稳态的关键调节因子。它与上皮屏障功能的多个方面有关，包括调节上皮细胞的生长和通透性、黏液和抗菌蛋白（AMPs）的产生以及补体的产生。在本综述中，我们特别关注 IL-22 在肠道上皮中的作用。我们总结了最近在理解 IL-22 如何调节稳态和宿主防御方面的进展，并讨论了 IL-22 途径作为肠道疾病（包括炎症性肠病（IBD）、移植物抗宿主病（GVHD）和癌症）的治疗靶点。
