Nunes Tiago, Bernardazzi Claudio, de Souza Heitor S
Nutrition and Immunology Chair, Research Center for Nutrition and Food Sciences (ZIEL), Technische Universität München, Gregor-Mendel-Straße 2, 85354 Freising-Weihenstephan, Germany.
Serviço de Gastroenterologia & Laboratório Multidisciplinar de Pesquisa, Hospital Universitario, Universidade Federal do Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco 255, Ilha do Fundão, 21941-913 Rio de Janeiro, RJ, Brazil.
Mediators Inflamm. 2014;2014:423957. doi: 10.1155/2014/423957. Epub 2014 Feb 20.
Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity. IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with the defense against parasitic infections of the gastrointestinal tract. In addition, it has been proposed that IL-33 can act as a signaling molecule alerting the immune system of danger or tissue damage. Recently, in the intestinal mucosa, overexpression of IL-33 has been reported in samples from patients with inflammatory bowel diseases (IBD). This review highlights the available data regarding IL-33 in human IBD and discusses emerging roles for IL-33 as a key modulator of intestinal inflammation.
白细胞介素-（IL-）33是一种广泛表达的细胞因子，存在于不同类型的细胞中，如上皮细胞、间充质细胞和炎症细胞，在固有免疫中发挥主要作用。IL-33可作为促炎细胞因子发挥作用，诱导Th2型免疫反应，参与抵御胃肠道寄生虫感染。此外，有人提出IL-33可作为一种信号分子，提醒免疫系统注意危险或组织损伤。最近，在肠道黏膜中，炎症性肠病（IBD）患者的样本中已报道IL-33表达上调。本综述重点介绍了有关人类IBD中IL-33的现有数据，并讨论了IL-33作为肠道炎症关键调节因子的新作用。
