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Adding Fat to the Fire: Does Lipidated IL-22 Promote Mucosal Healing in Patients with Inflammatory Bowel Disease Treated with Immunomodulators?

作者信息

Söderholm Johan Dabrosin

机构信息

Department of Surgery and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

出版信息

Dig Dis Sci. 2025 Jun 23. doi: 10.1007/s10620-025-09169-7.

DOI:10.1007/s10620-025-09169-7
PMID:40549241
Abstract
摘要

相似文献

1
Adding Fat to the Fire: Does Lipidated IL-22 Promote Mucosal Healing in Patients with Inflammatory Bowel Disease Treated with Immunomodulators?火上浇油：脂质化白细胞介素-22能否促进接受免疫调节剂治疗的炎症性肠病患者的黏膜愈合？
Dig Dis Sci. 2025 Jun 23. doi: 10.1007/s10620-025-09169-7.
2
Lipidated IL-22 Alone or Combined with Immunomodulatory Agents Improves Disease Endpoints and Promotes Mucosal Healing in a Mouse Model of Chronic Dextran Sodium Sulfate-Induced Colitis.脂质化白细胞介素-22单独或与免疫调节药物联合使用可改善疾病终点，并促进慢性葡聚糖硫酸钠诱导的小鼠结肠炎模型中的黏膜愈合。
Dig Dis Sci. 2025 Mar 26. doi: 10.1007/s10620-025-09007-w.
3
Epidemiology and Steroid Dependency Reduction in Crohn's Disease During the Biologics Era: A Nationwide Population-Based Study.生物制剂时代克罗恩病的流行病学及类固醇依赖减少：一项基于全国人口的研究
Adv Ther. 2025 Jun 23. doi: 10.1007/s12325-025-03245-0.
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Promotion of wound healing by acetate in murine colonic epithelial cell via c-Jun N-terminal kinase activation.通过激活 c-Jun N 端激酶促进乙酸盐在小鼠结肠上皮细胞中的伤口愈合。
J Gastroenterol Hepatol. 2020 Jul;35(7):1171-1179. doi: 10.1111/jgh.14987. Epub 2020 Feb 6.
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Acta Biomater. 2025 Jun 15;200:452-463. doi: 10.1016/j.actbio.2025.05.034. Epub 2025 May 14.
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Insights Imaging. 2025 Jun 16;16(1):125. doi: 10.1186/s13244-025-02014-5.

本文引用的文献

1
Lipidated IL-22 Alone or Combined with Immunomodulatory Agents Improves Disease Endpoints and Promotes Mucosal Healing in a Mouse Model of Chronic Dextran Sodium Sulfate-Induced Colitis.脂质化白细胞介素-22单独或与免疫调节药物联合使用可改善疾病终点，并促进慢性葡聚糖硫酸钠诱导的小鼠结肠炎模型中的黏膜愈合。
Dig Dis Sci. 2025 Mar 26. doi: 10.1007/s10620-025-09007-w.
2
A Randomized Phase II Study of Efmarodocokin Alfa, an interleukin-22 Agonist, Versus Vedolizumab in Patients With Ulcerative Colitis.一项关于白细胞介素-22激动剂阿法依泊金与维多珠单抗治疗溃疡性结肠炎患者的随机II期研究。
Clin Gastroenterol Hepatol. 2025 Jul;23(8):1387-1397. doi: 10.1016/j.cgh.2024.11.013. Epub 2024 Dec 16.
3
Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis.
依珐莫司他在健康志愿者和溃疡性结肠炎患者中的剂量递增随机研究。
Gut. 2023 Aug;72(8):1451-1461. doi: 10.1136/gutjnl-2022-328387. Epub 2023 Feb 2.
4
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease.白细胞介素 22 治疗可预防柠檬酸杆菌诱导的结肠炎模型中的上皮功能障碍，该模型与炎症性肠病具有相似性。
Mucosal Immunol. 2022 Jun;15(6):1338-1349. doi: 10.1038/s41385-022-00577-w. Epub 2022 Nov 13.
5
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.优化的人肠道类器官模型揭示了潘氏细胞形成对白细胞介素-22 的依赖性。
Cell Stem Cell. 2022 Sep 1;29(9):1333-1345.e6. doi: 10.1016/j.stem.2022.08.002. Epub 2022 Aug 23.
6
IL-22 and Lactobacillus delbrueckii mitigate alcohol-induced exacerbation of DSS-induced colitis.白细胞介素 22 和德氏乳杆菌缓解酒精诱导的 DSS 诱导结肠炎恶化。
J Leukoc Biol. 2022 Dec;112(6):1471-1484. doi: 10.1002/JLB.4A0122-068R. Epub 2022 Aug 2.
7
The future of drug development for inflammatory bowel disease: the need to ACT (advanced combination treatment).炎症性肠病药物研发的未来：采用ACT（先进联合治疗）的必要性。
Gut. 2022 Dec;71(12):2380-2387. doi: 10.1136/gutjnl-2022-327025. Epub 2022 Jun 14.
8
Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration.白细胞介素-22 信号通过促进上皮细胞再生来减轻坏死性小肠结肠炎。
Cell Rep Med. 2021 Jun 15;2(6):100320. doi: 10.1016/j.xcrm.2021.100320.
9
The role of IL-22 in intestinal health and disease.IL-22 在肠道健康和疾病中的作用。
J Exp Med. 2020 Feb 13;217(3):e20192195. doi: 10.1084/jem.20192195. Print 2020 Mar 2.
10
Increased Intestinal Permeability Is Associated With Later Development of Crohn's Disease.肠道通透性增加与克罗恩病的后期发展有关。
Gastroenterology. 2020 Dec;159(6):2092-2100.e5. doi: 10.1053/j.gastro.2020.08.005. Epub 2020 Aug 10.