The association of human leukocyte antigen class II (HLA II) haplotypes with the risk of Latent autoimmune diabetes of adults (LADA): Evidence based on available data.

AIMS

Latent autoimmune diabetes in adult (LADA), classified as between type 1 and type 2 diabetes mellitus, has received widespread attention. A number of studies have investigated the association between HLA DQA-DQB, DRB-DQB haplotypes and the onset of LADA. However, the conclusions remained inconsistent. Therefore, this study aims to clarify the impact of these HLA haplotypes on the pathogenesis of LADA.

METHODS

Systematic searches were carried out on the Medline, PubMed, Embase and Wan Fang respectively to investigate the association of LADA with HLA DQA-DQB, DRB-DQB up to June 05, 2020. We performed this retrospective research using meta-analysis.

RESULTS

The pooled results demonstrated that in Chinese, DQA105-DQB10201, DQA103-DQB10401, and DQA103-DQB10303 were statistically significantly associated with increasing the risk of LADA (P < 0.001), while DQA10102-DQB10602 was statistically significantly correlated with decreasing the susceptibility to the disease (P = 0.003). However, there was no obvious association found between DQA10201-DQB10201 (P = 0.984), DQA103-DQB10302 (P = 0.110), DQA10601-DQB10301 (P = 0.398) and LADA. In Japanese, DRB10802-DQB10302 (P = 0.003) and DRB10901-DQB10303 (P = 0.001), but not DRB10405-DQB10401 (P = 0.136), were found to be a risk factor for LADA. As for Caucasian, both DRB103-DQB10201 and DRB104-DQB10302 were predisposed to the development of LADA with a statistical significance (P < 0.001).

CONCLUSION

In all, HLA DQA-DQB, HLA DRB-DQB haplotypes might play a role in the risk of LADA, which could provide an improved understanding of LADA pathogenesis and the detection of susceptible HLA haplotypes in the diagnosis and therapy of this disease.