UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Biotechnology Programme, Faculty of Science and Natural Resources, Universiti Malaysia Sabah, Kota Kinabalu 88400, Malaysia.
Biomolecules. 2020 Sep 28;10(10):1378. doi: 10.3390/biom10101378.
The Krüppel-like factors (KLFs) family of proteins control several key biological processes that include proliferation, differentiation, metabolism, apoptosis and inflammation. Dysregulation of KLF functions have been shown to disrupt cellular homeostasis and contribute to disease development. KLF6 is a relevant example; a range of functional and expression assays suggested that the dysregulation of KLF6 contributes to the onset of cancer, inflammation-associated diseases as well as cardiovascular diseases. KLF6 expression is either suppressed or elevated depending on the disease, and this is largely due to alternative splicing events producing KLF6 isoforms with specialised functions. Hence, the aim of this review is to discuss the known aspects of KLF6 biology that covers the gene and protein architecture, gene regulation, post-translational modifications and functions of KLF6 in health and diseases. We put special emphasis on the equivocal roles of its full-length and spliced variants. We also deliberate on the therapeutic strategies of KLF6 and its associated signalling pathways. Finally, we provide compelling basic and clinical questions to enhance the knowledge and research on elucidating the roles of KLF6 in physiological and pathophysiological processes.
Krüppel 样因子 (KLF) 蛋白家族控制着多种关键的生物学过程，包括增殖、分化、代谢、凋亡和炎症。KLF 功能的失调已被证明会破坏细胞内稳态并导致疾病的发展。KLF6 就是一个相关的例子；一系列功能和表达分析表明，KLF6 的失调导致癌症、炎症相关疾病以及心血管疾病的发生。KLF6 的表达根据疾病的不同而受到抑制或上调，这主要是由于选择性剪接事件产生具有特殊功能的 KLF6 同工型。因此，本综述的目的是讨论 KLF6 生物学的已知方面，包括基因和蛋白质结构、基因调控、翻译后修饰以及 KLF6 在健康和疾病中的功能。我们特别强调其全长和剪接变体的模棱两可作用。我们还讨论了 KLF6 及其相关信号通路的治疗策略。最后，我们提供了有说服力的基础和临床问题，以增强对阐明 KLF6 在生理和病理生理过程中的作用的知识和研究。
