类Krüppel转录因子KLF6和KLF15在近端小管代谢中的作用
Roles of Krüppel-Like Transcription Factors KLF6 and KLF15 in Proximal Tubular Metabolism.
作者信息
Piret Sian E
机构信息
Division of Nephrology and Hypertension, Department of Medicine, Stony Brook University, Stony Brook, New York, USA.
出版信息
Nephron. 2023;147(12):766-768. doi: 10.1159/000531336. Epub 2023 Jun 1.
PMID:37263229
Abstract
Members of the Krüppel-like family of transcription factors are widely expressed, including in the kidney. Expression of some KLFs changes in acute kidney injury, and this may be adaptive or maladaptive, and result in effects on various cellular pathways. This mini-review will highlight the roles of KLF6 and KLF15 in control of proximal tubular cell metabolism.
摘要
Krüppel样转录因子家族成员广泛表达，包括在肾脏中。一些Krüppel样因子（KLFs）的表达在急性肾损伤中会发生变化，这可能是适应性的或适应不良的，并导致对各种细胞途径产生影响。本综述将重点介绍KLF6和KLF15在近端肾小管细胞代谢调控中的作用。
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