Laboratorio de Virología, Departamento de Infectología del Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Colonia Lomas de los Virreyes, Delegación Miguel Hidalgo, Ciudad de México, Mexico.
Laboratorio de Investigación Clínica y Ambiental, Departamento de Microbiología de la Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Delegación Miguel Hidalgo, Ciudad de México, Mexico.
Int J STD AIDS. 2020 Nov;31(13):1255-1262. doi: 10.1177/0956462420947587. Epub 2020 Sep 30.
Not all human papillomavirus (HPV) infections develop into cervical cancer (CC), so it is proposed that other factors may influence this, such as co-infection with (CT). To identify the prevalence of co-infection, we included 189 women with suspicion of HPV. Viral typing was performed by carrying out the Roche HP Linear Array test, while CT detection was performed with the COBAS® TaqMan® 48 kit from Roche. Of the 189 women only 184 had an infection with HPV, CT or both: 56.6% were positive for one or several HPV genotypes, and 67.7% for CT. Clinical data showed an association between HPV and CIN I (n = 22; RR = 2.43; 95% CI 1.72-3.43, p < 0.05). CT infection was only associated with cervicitis (n = 40; RR = 1.73; 95% CI 1.34-2.23, p < 0.05). The CT-HPV co-infection rate was 28%. Co-infection revealed an association with CIN I (n = 31, RR= 3.33; 95% CI 2.08-5.34 p < 0.05), CIN III (n = 7; RR = 2.57; 95% CI 1.53-4.31, p < 0.05); and a significant risk of 2.3 (95% CI 1.08-4.90) times higher to develop CC; nevertheless, this risk was not statistically significant. CT/HPV co-infection was associated with the development of a high-grade lesion (CIN III) as well as an important risk for developing CC.
并非所有人类乳头瘤病毒（HPV）感染都会发展成宫颈癌（CC），因此有人提出其他因素可能会影响这一点，例如合并感染 （CT）。为了确定合并感染的流行率，我们纳入了 189 名疑似 HPV 感染的女性。病毒分型通过罗氏 HP Linear Array 试验进行，而 CT 检测则使用罗氏 COBAS® TaqMan® 48 试剂盒进行。在这 189 名女性中，只有 184 名感染了 HPV、CT 或两者都有：56.6%的人感染了一种或多种 HPV 基因型，67.7%的人感染了 CT。临床数据显示 HPV 与 CIN I 之间存在关联（n=22；RR=2.43；95%CI 1.72-3.43，p<0.05）。CT 感染仅与宫颈炎相关（n=40；RR=1.73；95%CI 1.34-2.23，p<0.05）。CT-HPV 合并感染率为 28%。合并感染与 CIN I（n=31，RR=3.33；95%CI 2.08-5.34 p<0.05）、CIN III（n=7；RR=2.57；95%CI 1.53-4.31，p<0.05）有关；并且发生 CC 的风险显著增加 2.3 倍（95%CI 1.08-4.90）；然而，这种风险没有统计学意义。CT/HPV 合并感染与高级别病变（CIN III）的发生以及发生 CC 的重要风险有关。
