Department of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, China.
Department of Clinical Laboratory, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Front Public Health. 2022 Sep 26;10:1002029. doi: 10.3389/fpubh.2022.1002029. eCollection 2022.
The global incidence of genital infection increased rapidly as the primary available treatment of infection being the use of antibiotics. However, the development of antibiotics resistant stain and other treatment failures are often observed in patients. Consequently, novel therapeutics are urgently required. Rhein is a monomer derivative of anthraquinone compounds with an anti-infection activity. This study investigated the effects of rhein on treating infection. Rhein showed significant inhibitory effects on the growth of in multiple serovars of , including D, E, F and L1, and in various host cells, including HeLa, McCoy and Vero. Rhein could not directly inactivate but could inhibit the growth of by regulating pathogen-host cell interactions. Combined with azithromycin, the inhibitory effect of rehin was synergistic both and . Together these findings suggest that rhein could be developed for the treatment of infections.
随着抗生素成为治疗感染的主要手段，全球生殖器感染的发病率迅速上升。然而，患者经常出现抗生素耐药菌株和其他治疗失败的情况。因此，迫切需要新的治疗方法。大黄酸是蒽醌类化合物的单体衍生物，具有抗感染活性。本研究探讨了大黄酸治疗感染的效果。大黄酸对多种血清型的生长具有显著的抑制作用，包括 D、E、F 和 L1，以及在多种宿主细胞中，包括 HeLa、McCoy 和 Vero。大黄酸不能直接灭活，但可以通过调节病原体-宿主细胞相互作用来抑制的生长。与阿奇霉素联合使用时，大黄酸对和的抑制作用具有协同作用。这些发现表明，大黄酸可开发用于治疗感染。
