Aaslid R
Stroke. 1987 Jul-Aug;18(4):771-5. doi: 10.1161/01.str.18.4.771.
The dynamics of the metabolic mechanism that regulates cerebral blood flow was studied in 10 normal human subjects using a noninvasive transcranial ultrasonic Doppler method. Flow volume in the posterior cerebral artery, supplying the visual cortex, increased 20.2% in response to light stimulation of the retina, while flow velocity in the same artery increased 16.4%. The regulation of blood flow was very rapid; only 2.3 seconds elapsed from application of the light stimulus to 50% of full response. Full regulation (90% of full response) took 4.6 seconds. The blood flow response adapted slightly after about 10 seconds. Flow velocity in the middle cerebral artery increased significantly, by 3.3%, while flow in the superior cerebellar artery showed no significant change in response to this stimulus. These findings suggest the mechanism of very fast metabolic regulation of cerebral blood flow in humans.
采用无创经颅超声多普勒方法，对10名正常受试者调节脑血流量的代谢机制动态进行了研究。供应视觉皮层的大脑后动脉血流量，在视网膜受到光刺激时增加了20.2%，而同一动脉的血流速度增加了16.4%。血流调节非常迅速；从施加光刺激到达到最大反应的50%仅经过2.3秒。完全调节（最大反应的90%）需要4.6秒。大约10秒后血流反应略有适应。大脑中动脉的血流速度显著增加，增加了3.3%，而小脑上动脉的血流对该刺激无显著变化。这些发现提示了人类脑血流量非常快速的代谢调节机制。
