Division of Experimental Oncology/Unit of Urology; URI; IRCCS Ospedale San Raffaele, Milan, Italy.
University Vita-Salute San Raffaele, Milan, Italy.
Int J Impot Res. 2021 May;33(4):418-427. doi: 10.1038/s41443-020-00357-9. Epub 2020 Sep 30.
Focal therapy modalities achieved interest in the management of prostate cancer (PCa) over the last a few years. This systematic review was aimed to investigate erectile function after focal therapy for localized PCa. Twenty-six out of 1287 reports were identified through a database systematic search in MEDLINE, EMBASE, and Web of Science, supplemented with hand search, on June 1st, 2020, according to PRISMA guidelines. Focal therapy modalities investigated were cryotherapy, high-intensity focused ultrasound (HIFU), photodynamic therapy (TOOKAD), irreversible electroporation (IRE), and focal radiotherapy (RT) (i.e. brachytherapy or stereotactic RT). Overall, reported sexual function outcomes after these treatment modalities were generally good, with many studies reporting a complete recovery of EF at 1-year follow-up. However, the quality of current evidence is affected both by the lack of well-conducted comparative studies and by a significant heterogeneity in terms of study design, study population, erectile and sexual function assessment modalities.
在过去的几年中，局灶性治疗方法在前列腺癌（PCa）的治疗中引起了关注。本系统评价旨在研究局限性前列腺癌局灶治疗后的勃起功能。通过 2020 年 6 月 1 日在 MEDLINE、EMBASE 和 Web of Science 数据库中的系统搜索，以及手检，共确定了 1287 份报告中的 26 份，符合 PRISMA 指南。研究的局灶治疗方法包括冷冻疗法、高强度聚焦超声（HIFU）、光动力疗法（TOOKAD）、不可逆电穿孔（IRE）和局灶放射治疗（RT）（即近距离放疗或立体定向 RT）。总的来说，这些治疗方法后的性功能报告结果通常较好，许多研究报告在 1 年随访时 EF 完全恢复。然而，目前证据的质量受到缺乏精心设计的对照研究以及在研究设计、研究人群、勃起和性功能评估方法方面存在显著异质性的影响。
