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加拿大背景下前列腺癌聚焦治疗的探索:当代观点与未来发展轨迹

Navigating Focal Therapy for Prostate Cancer: Contemporary Perspectives and Future Trajectories in the Canadian Context.

作者信息

Hesswani Charles, Avolio Pier-Paolo, Rompre-Brodeur Alexis, Ghai Sangeet, Anidjar Maurice, Kinnaird Adam, Chin Joseph, Perlis Nathan, Soytas Mostapha, Mannas Miles, Ahmad Ardalanejaz, Klotz Lawrence, Tanguay Simon, Kassouf Wassim, McPherson Victor, Aprikian Armen, Pinto Peter, Sanchez-Salas Rafael

机构信息

Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Division of Urology, Department of Surgery, McGill University Health Centre, Montreal, Canada.

出版信息

J Endourol. 2025 Mar;39(S2):S29-S37. doi: 10.1089/end.2024.0619. Epub 2024 Nov 29.

Abstract

This article equips Canadian urologists with the latest advancements in focal therapy (FT) principles and outcomes while providing an overview of its current landscape in Canada, including challenges and future directions. We conducted a nonsystematic review of the literature on FT in urology and prostate cancer (PCa), focusing on Canadian-led studies. Articles were identified using PubMed, MEDLINE, and Google Scholar and selected based on relevance and originality. The final search was completed in April 2024. A survey was also conducted among Canadian urologists and radiologists practicing FT. It covered their experiences, access to technology, implementation challenges, and reimbursement policies. Data were collected via video calls, phone calls, or email, and responses were reported anonymously. Fourteen Canadian urologists and radiologists performing FT were contacted, and 12 participated in this study. Despite the increasing adoption of FT by Canadian urologists, nationwide implementation remains limited due to financial constraints and resource shortages. This has restricted the availability of FT for Canadian men with PCa compared with their American and European counterparts. Only two provinces-Saskatchewan and Alberta-currently have billing codes for FT, forcing patients elsewhere to either join clinical trials or pay out of pocket. To close this care gap, equitable health care coverage and integration of FT into standard treatment options are essential. The quality of research in FT is showing promising improvements, with several clinical trials currently underway that may pave the way for broader acceptance within clinical guidelines by multiple urological societies. Although Canada has been slower to adopt FT compared with other parts of the world, Canadian urologists continue to advocate for provincial health care coverage to ensure that this innovative technology becomes accessible to Canadian patients.

摘要

本文为加拿大泌尿外科医生提供了聚焦治疗(FT)原则和成果的最新进展,同时概述了其在加拿大的现状,包括挑战和未来方向。我们对泌尿外科和前列腺癌(PCa)聚焦治疗的文献进行了非系统性综述,重点关注加拿大主导的研究。通过PubMed、MEDLINE和谷歌学术搜索确定文章,并根据相关性和原创性进行筛选。最终搜索于2024年4月完成。我们还对从事聚焦治疗的加拿大泌尿外科医生和放射科医生进行了一项调查。调查涵盖了他们的经验、技术获取情况、实施挑战和报销政策。通过视频通话、电话或电子邮件收集数据,回答以匿名方式报告。我们联系了14位进行聚焦治疗的加拿大泌尿外科医生和放射科医生,其中12位参与了本研究。尽管加拿大泌尿外科医生对聚焦治疗的采用率不断提高,但由于资金限制和资源短缺,全国范围内的实施仍然有限。与美国和欧洲同行相比,这限制了加拿大前列腺癌男性患者获得聚焦治疗的机会。目前只有萨斯喀彻温省和艾伯塔省这两个省份有聚焦治疗的计费代码,迫使其他地区的患者要么参加临床试验,要么自掏腰包。为了缩小这一医疗差距,公平的医疗覆盖以及将聚焦治疗纳入标准治疗方案至关重要。聚焦治疗的研究质量正在显示出有希望的改善,目前有几项临床试验正在进行中,这可能为多个泌尿外科协会在临床指南中更广泛地接受该治疗方法铺平道路。尽管与世界其他地区相比,加拿大采用聚焦治疗的速度较慢,但加拿大泌尿外科医生继续倡导省级医疗覆盖,以确保加拿大患者能够获得这项创新技术。

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