Rehm S, Sommer R, Deerberg F
Vet Pathol. 1987 May;24(3):216-25. doi: 10.1177/030098588702400304.
A life span study of 900 female virgin Han:NMRI mice (300 outbred controls, 300 of a fat subline, and 300 of a lean subline) was done to determine the occurrence of spontaneous disease with ad libitum or restricted feeding. Major nonneoplastic lesions in the glandular stomach were erosions, ulcers and adenomatous hyperplasia of the fundus. Ulcers, ranging in incidence with ad libitum feeding from 5 to 9% and with food restriction from 13 to 34%, either occurred secondary to other diseases or were due to stress associated with food restriction, causing death mainly in the lean subline. Adenomatous hyperplasia was most common in the control group (41%); the frequency increased with age and was significantly reduced by food restriction. The etiology of adenomatous gastric hyperplasia is yet unknown. However, a lack of antiparietal cell antibodies, as determined by an immunofluorescent technique, indicates that an autoimmune disorder is not involved and an increase in antral gastrin cells, as determined by avidin-biotin peroxidase immunocytochemistry, suggests a hormonal involvement in pathogenesis.
对900只雌性纯种Han:NMRI小鼠（300只远交对照组、300只肥胖亚系和300只瘦亚系）进行了一项寿命研究，以确定自由采食或限食情况下自发性疾病的发生情况。腺胃的主要非肿瘤性病变为糜烂、溃疡和胃底腺瘤样增生。溃疡在自由采食组的发生率为5%至9%，在限食组为13%至34%，其发生要么继发于其他疾病，要么是由于限食相关的应激，主要导致瘦亚系小鼠死亡。腺瘤样增生在对照组最为常见（41%）；其发生率随年龄增加而升高，限食可使其显著降低。胃腺瘤样增生的病因尚不清楚。然而，免疫荧光技术检测显示缺乏抗壁细胞抗体，这表明不涉及自身免疫性疾病，而抗生物素蛋白-生物素过氧化物酶免疫细胞化学检测显示胃窦胃泌素细胞增多，提示激素参与了发病机制。
