Rehm S, Dierksen D, Deerberg F
J Natl Cancer Inst. 1984 Jun;72(6):1383-95.
In a life-span study with female Han:NMRI virgin mice (300 of a fat subline, 300 of a lean subline, and 300 controls), a total of 424 mice developed 673 ovarian tumors. Half of the mice in each group were fed ad libitum, and for the other half food was restricted. Most prevalent were tubular adenomas followed by granulosa and Sertoli cell tumors. Altogether, 42 neoplasms were classified as tubular adenocarcinomas, and 21, as luteomas . The general incidence of tumors increased sharply beyond the 18th month of age. Granulosa cell tumors arose relatively early, and tubular adenocarcinomas occurred very late in life. The occurrence of ovarian tumors depended mainly on life expectancy. All animals subjected to food restriction lived longer and developed more ovarian neoplasms than those fed ad libitum.
在一项针对雌性Han:NMRI处女小鼠（300只肥胖亚系、300只瘦亚系和300只对照小鼠）的寿命研究中，共有424只小鼠发生了673个卵巢肿瘤。每组一半的小鼠自由进食，另一半则进行食物限制。最常见的是管状腺瘤，其次是颗粒细胞瘤和支持细胞瘤。总共有42个肿瘤被归类为管状腺癌，21个为黄体瘤。肿瘤的总体发生率在18个月龄后急剧上升。颗粒细胞瘤出现相对较早，而管状腺癌在生命后期才出现。卵巢肿瘤的发生主要取决于预期寿命。所有接受食物限制的动物比自由进食的动物寿命更长，发生的卵巢肿瘤更多。
