Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
J Gastroenterol Hepatol. 2021 May;36(5):1267-1275. doi: 10.1111/jgh.15282. Epub 2020 Oct 14.
Most patients with gastric tumors and precancerous lesions are asymptomatic, which often results in delayed diagnosis and treatment. Compared with conventional gastroscopy and capsule endoscopy, magnetic-controlled capsule endoscopy is a non-invasive, effective, and cost-efficient diagnostic modality for gastric examination. We retrospectively investigated magnetic-controlled capsule endoscopy as a screening tool for gastrointestinal lesions (particularly gastric tumors and precancerous lesions) in asymptomatic individuals.
In this retrospective study, 1757 patients who voluntarily underwent magnetic-controlled capsule endoscopy between January and December 2019 at nine medical centers across Shaanxi province based on strict inclusion and exclusion criteria were enrolled. The primary outcomes were gastric tumor and precancerous lesion detection rates and procedural safety.
The upper and lower gastrointestinal lesion detection rates were 98.35% (1728/1757) and 21.61% (78/361), respectively; 2.28% of patients were diagnosed with gastric tumors including gastric cancer (4/1757) and submucosal tumors (36/1757). Three types of precancerous lesions were found in 591 patients (33.64%), including chronic atrophic gastritis (23.16%), gastric polyp (10.98%), and gastric ulcer (2.96%). For patients aged over 40 years, the detection rate of precancerous lesions was higher (14.36% vs 42.58%, P < 0.001). No patient was diagnosed with small intestinal cancer. No adverse events occurred.
Magnetic-controlled capsule endoscopy could be used as a promising novel screening modality for diagnosis of gastrointestinal lesions in asymptomatic individuals, specifically gastric tumors and precancerous lesions, with the advantages of safety, non-invasiveness, effectiveness, and cost-efficiency.
大多数胃肿瘤和癌前病变患者无症状，这往往导致诊断和治疗延误。与传统胃镜和胶囊内镜相比，磁控胶囊内镜是一种非侵入性、有效且具有成本效益的胃部检查诊断方式。我们回顾性研究了磁控胶囊内镜作为一种筛查无症状个体胃肠道病变（特别是胃肿瘤和癌前病变）的工具。
在这项回顾性研究中，根据严格的纳入和排除标准，我们纳入了 2019 年 1 月至 12 月在陕西省 9 家医疗中心自愿接受磁控胶囊内镜检查的 1757 例患者。主要结局是胃肿瘤和癌前病变的检出率和程序安全性。
上消化道和下消化道病变的检出率分别为 98.35%（1728/1757）和 21.61%（78/361）；2.28%的患者被诊断为胃肿瘤，包括胃癌（4/1757）和黏膜下肿瘤（36/1757）。591 例患者发现了 3 种癌前病变（33.64%），包括慢性萎缩性胃炎（23.16%）、胃息肉（10.98%）和胃溃疡（2.96%）。对于年龄超过 40 岁的患者，癌前病变的检出率更高（14.36%比 42.58%，P<0.001）。没有患者被诊断为小肠癌。没有发生不良事件。
磁控胶囊内镜可作为一种有前途的新型筛查手段，用于诊断无症状个体的胃肠道病变，特别是胃肿瘤和癌前病变，具有安全、非侵入性、有效性和成本效益的优点。
