Department of Otorhinolaryngology, Örebro University Hospital, Örebro, Sweden.
Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Ann Otol Rhinol Laryngol. 2021 May;130(5):504-512. doi: 10.1177/0003489420962822. Epub 2020 Oct 1.
This study comprised a long-term follow-up of a cohort of patients with chronic rhinosinusitis (CRS) regarding clinical features and symptomatology.
Data from 42 patients with CRS were available from a previous study. Forty of these patients were alive and were contacted for inclusion after approximately 10 years. Patients completed a questionnaire about disease and symptoms, and underwent a clinical examination.
Thirty-four patients (85%) responded and could be included and evaluated. For the participants in this follow-up study median length of time between initial inclusion (C1) and follow-up (C2) was 11 years (range: 8-15). In some patients the CRS shifted phenotype over time, from CRS with nasal polyposis to CRS without nasal polyposis or vice versa. The median total visual analogue score for combined sinonasal symptoms for all patients was statistically significantly reduced at follow-up. For individual patients, scores for nasal congestion, nasal discharge, facial pressure, and hyposmia were also statistically significantly reduced. The most frequently reported symptom-relieving treatments were nasal steroids and saline rinsing of the nose. Self-reported general quality of life was statistically significantly improved at C2 compared to C1.
At long-term follow-up, symptoms were generally reduced and patients reported an improved quality of life. Patients can be given hope for eventual symptom relief. CRS is a chronic condition that seems to harbor the ability to alter its phenotype after several years. Topical corticosteroids and saline rinsing of the nose should be emphasized, since patients consider these treatments to be of high value.
本研究对一组慢性鼻-鼻窦炎（CRS）患者进行了长期随访，以了解其临床特征和症状。
先前研究中提供了 42 例 CRS 患者的数据。其中 40 例患者存活并在大约 10 年后被联系纳入研究。患者完成了一份关于疾病和症状的问卷，并接受了临床检查。
34 名患者（85%）作出回应并可被纳入和评估。对于本随访研究的参与者，首次纳入（C1）和随访（C2）之间的中位时间为 11 年（范围：8-15 年）。在一些患者中，CRS 表型随时间发生变化，从伴有鼻息肉的 CRS 转变为不伴鼻息肉的 CRS 或反之亦然。所有患者的综合鼻-鼻窦症状总视觉模拟评分在随访时统计学显著降低。对于个别患者，鼻塞、鼻涕、面部压力和嗅觉减退的评分也统计学显著降低。报告最频繁的缓解症状的治疗方法是鼻用皮质类固醇和鼻腔盐水冲洗。与 C1 相比，C2 时自我报告的一般生活质量统计学显著提高。
在长期随访中，症状通常会减轻，患者报告生活质量提高。可以让患者对最终的症状缓解抱有希望。CRS 是一种慢性疾病，似乎在几年后有改变其表型的能力。应强调鼻用皮质类固醇和鼻腔盐水冲洗，因为患者认为这些治疗方法具有很高的价值。
