State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China.
School of Medicine, University of California, San Diego, CA 92103, United States.
Curr Pharm Des. 2021;27(6):840-854. doi: 10.2174/1381612826666201001125124.
Depression is a widespread and persistent psychiatric disease. Due to various side effects and no curative treatments of conventional antidepressant drugs, botanical medicines have attracted considerable attention as a complementary and alternative approach. The pathogenesis of depression is quite complicated and unclear. Metabolomics is a promising new technique for the discovery of novel biomarkers for exploring the potential mechanisms of diverse diseases and assessing the therapeutic effects of drugs. In this article, we systematically reviewed the study of botanical medicine for the treatment of depression using metabolomics over a period from 2010 to 2019. Additionally, we summarized the potential biomarkers and metabolic pathways associated with herbal medicine treatment for depression. Through a comprehensive evaluation of herbal medicine as novel antidepressants and understanding of their pharmacomechanisms, a new perspective on expanding the application of botanical medicines for the treatment of depression is provided.
抑郁症是一种广泛且持续存在的精神疾病。由于传统抗抑郁药存在各种副作用且没有治愈方法，因此作为一种补充和替代疗法，植物药引起了相当大的关注。抑郁症的发病机制非常复杂且尚不清楚。代谢组学是一种很有前途的新技术，可用于发现新的生物标志物以探索各种疾病的潜在机制，并评估药物的治疗效果。在本文中，我们系统地回顾了 2010 年至 2019 年期间使用代谢组学研究植物药治疗抑郁症的情况。此外，我们总结了与草药治疗抑郁症相关的潜在生物标志物和代谢途径。通过全面评估植物药作为新型抗抑郁药以及了解其药物作用机制，为扩大植物药治疗抑郁症的应用提供了新的视角。
