National Chinmedomics Research Center, Functional Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, China.
State Key Laboratory of Dampness Syndrome, The Second Affiliated Hospital Guangzhou University of Chinese Medicine, Dade Road 111, Guangzhou, China.
Trends Endocrinol Metab. 2023 Mar;34(3):146-157. doi: 10.1016/j.tem.2023.01.005. Epub 2023 Jan 28.
Evidence shows that herbal medicine (HM) could be beneficial for the treatment of various diseases. However, complexities present in HM due to the unclear bioactive compounds, mechanisms of action, undetermined targets for therapy, and nonspecific features for metabolism, are currently an obstacle for the progression of novel drug discovery. Metabolomics could be a potential tool to overcome these issues and for the understanding of HM from a small-molecule metabolism level. The chinmedomics-based metabolomics method assesses the overall metabolism of organisms with a holistic view and shows great potential for understanding metabolic pathways, evaluating curative effects, clarifying mechanisms, discovering active ingredients, and precision medicine. This review focuses on the efficacy evaluation, active ingredient discovery, and target exploration of HM based on metabolomics and chinmedomics.
证据表明，草药（HM）可能有益于治疗各种疾病。然而，由于生物活性化合物不明确、作用机制不确定、治疗靶点未确定以及代谢的非特异性特征等复杂性，目前这是新药发现进展的一个障碍。代谢组学可能是克服这些问题的一种潜在工具，有助于从小分子代谢水平理解 HM。基于中药组学的代谢组学方法从整体的角度评估生物体的整体代谢，对于理解代谢途径、评估疗效、阐明机制、发现活性成分和精准医学具有巨大潜力。本综述重点介绍了基于代谢组学和中药组学的 HM 的功效评价、活性成分发现和靶标探索。
