Ain Shams University, Cairo, Egypt.
J Cosmet Dermatol. 2021 Jun;20(6):1860-1866. doi: 10.1111/jocd.13747. Epub 2020 Oct 15.
The etiology of premature hair graying (PHG) remains incompletely understood with limited treatment options, although has profound impacts on patient's quality of life.
To assess demographic and clinical profiles of Egyptian PHG patients and explore association of various epidemiological risk factors and serum vitamin D and ferritin levels with PHG.
Three hundred PHG patients and equal number of controls, aged <30 years, were included. Assessment of epidemiological and clinical characteristics, biometric data and stress perception using perceived stress scale (PSS-10) was done, with measurement of serum vitamin D and ferritin levels for all subjects. PHG was graded into mild, moderate, and severe if <10, 10-100, and >100 gray hairs, respectively. Statistical significance for various compared parameters was done employing suitable tests, with P-value ≤ .05 considered significant.
Results reported significant positive relation of PHG with family history, sedentary life style, and stress (P = .001, .029, and .001, respectively), while no significant relation with smoking, body mass index, or frequent hair dyes use (>3 per year) (P = .425, .5, and .65, respectively). No significant difference was found in mean vitamin D between patients and controls (23.79 ± 13.01 ng/mL vs 24.85 ± 13.19 ng/mL, P = .701), while low serum ferritin (<20 ng/mL) was significantly associated with PHG (14.7 % patients vs 2.7% controls, P = .017).
PHG in Egyptian population is significantly associated with positive family history, stress, sedentary life style, and low serum ferritin level, while role of vitamin D deficiency should be further evaluated.
尽管有有限的治疗选择，但 Premature Hair Graying（PHG）的病因仍不完全清楚，这对患者的生活质量有深远的影响。
评估埃及 PHG 患者的人口统计学和临床特征，并探讨各种流行病学危险因素以及血清维生素 D 和铁蛋白水平与 PHG 的关系。
纳入了 300 名 PHG 患者和相同数量的对照组，年龄均<30 岁。对流行病学和临床特征、人体测量学数据以及使用感知压力量表（PSS-10）评估的压力感知进行评估，并对所有受试者进行血清维生素 D 和铁蛋白水平的测量。PHG 根据白发数量分为轻度（<10 根）、中度（10-100 根）和重度（>100 根）。对各种比较参数进行了适当的检验，P 值≤0.05 认为具有统计学意义。
结果报告 PHG 与家族史、久坐的生活方式和压力呈显著正相关（P=0.001、0.029 和 0.001），而与吸烟、体重指数或频繁使用染发剂（每年>3 次）无关（P=0.425、0.5 和 0.65）。患者和对照组的平均维生素 D 水平无显著差异（23.79±13.01ng/mL 与 24.85±13.19ng/mL，P=0.701），而低血清铁蛋白（<20ng/mL）与 PHG 显著相关（14.7%的患者与 2.7%的对照组，P=0.017）。
埃及人群中 PHG 与阳性家族史、压力、久坐的生活方式和低血清铁蛋白水平显著相关，而维生素 D 缺乏的作用需要进一步评估。
