Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cosmet Dermatol. 2020 Jun;19(6):1513-1516. doi: 10.1111/jocd.13173. Epub 2019 Sep 26.
The exact etiology of premature hair graying (PHG) remains unknown; however, oxidative stress is shown to be involved. Selenium, as an antioxidant, is widely known for its antiaging potentials. Moreover, PGH is more prevalent among addicts and because Lead is a common impurity found in illegal drug.
We evaluated the serum levels of lead and selenium in patients with PHG and compared it with a control group.
PATIENTS/METHODS: In this cross-sectional study, 60 patients referred to Dermatology Clinic of Imam-Reza Hospital of Mashhad, Iran in 2015 were evaluated in two groups with and without PHG. Demographic information and disease characteristics, skin phenotype, and family history of PHG were recorded. Furthermore, 5 mL of brachial blood was drawn for measuring selenium and lead levels.
The mean patients' age was 28.1 ± 4.8 years. Age, sex, occupation, and skin phenotype in individuals with and without PHG were not significantly different (P > .05) but family history of PHG was significantly higher in the patients with PHG (P = .001). Similarly, the number of white hairs was significantly higher (P < .001), and the age of onset of hair graying was significantly lower in patients with PHG (P < .001). Serum levels of selenium and lead were not significantly different between two groups (P < .05). However, the serum levels of lead in the patients with PHG were slightly higher.
The results of this study showed that there was no significant difference in lead and selenium serum levels in patients with and without PHG.
导致过早白发（PHG）的确切病因尚不清楚；然而，氧化应激被认为与之相关。硒作为一种抗氧化剂，因其抗衰老潜力而广为人知。此外，PHG 在吸毒者中更为普遍，因为铅是非法药物中常见的杂质。
我们评估了 PHG 患者的血清铅和硒水平，并将其与对照组进行了比较。
患者/方法：在这项横断面研究中，我们评估了 2015 年伊朗马什哈德伊玛目礼萨医院皮肤科诊所的 60 名患者，将他们分为有和无 PHG 两组。记录了人口统计学信息和疾病特征、皮肤表型和 PHG 的家族史。此外，抽取 5ml 肱动脉血测量硒和铅水平。
患者的平均年龄为 28.1±4.8 岁。有和无 PHG 的个体的年龄、性别、职业和皮肤表型无显著差异（P>.05），但 PHG 患者的 PHG 家族史明显更高（P=.001）。同样，白发数量明显更高（P<.001），PHG 患者的白发发病年龄明显更低（P<.001）。两组患者的血清硒和铅水平无显著差异（P>.05）。然而，PHG 患者的血清铅水平略高。
本研究结果表明，PHG 患者和无 PHG 患者的血清铅和硒水平无显著差异。
