Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, Korea.
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
J Am Acad Dermatol. 2015 Feb;72(2):321-7. doi: 10.1016/j.jaad.2014.11.008. Epub 2014 Dec 4.
Many researchers have been concerned about the association of hair graying with systemic diseases. However, the common factors associated with hair graying and systemic diseases have not been elucidated.
This study aimed to identify risk factors for premature hair graying (PHG) in young men.
We conducted a cross-sectional study using questionnaires in young men. After a pilot study that included 1069 men, we surveyed 6390 men younger than 30 years about their gray hair status and various socioclinical characteristics.
The age of participants in the main survey was 20.2 ± 1.3 years (mean ± SD). Of the 6390 participants, 1618 (25.3%) presented with PHG. Family history of PHG (odds ratio [OR], 12.82), obesity (OR, 2.61), and >5 pack-years history of smoking (OR, 1.61) were significantly associated with PHG. In the multivariate analysis, family history of PHG (OR, 2.63) and obesity (OR, 2.22) correlated with the severity of PHG.
Owing to the use of questionnaires, the possibility of recall bias exists. Women were not evaluated in this study.
Smoking, family history of PHG, and obesity are important factors associated with PHG.
许多研究人员一直关注头发变白与全身疾病的关系。然而，与头发变白和全身疾病相关的常见因素尚未阐明。
本研究旨在确定年轻男性早发性白发（PHG）的危险因素。
我们使用问卷对年轻男性进行了横断面研究。在包括 1069 名男性的预试验研究之后，我们调查了 6390 名年龄小于 30 岁的男性的白发状况和各种社会临床特征。
主要调查参与者的年龄为 20.2 ± 1.3 岁（均值 ± SD）。在 6390 名参与者中，1618 名（25.3%）出现 PHG。有 PHG 家族史（比值比[OR]，12.82）、肥胖（OR，2.61）和 >5 包年吸烟史（OR，1.61）与 PHG 显著相关。在多变量分析中，有 PHG 家族史（OR，2.63）和肥胖（OR，2.22）与 PHG 的严重程度相关。
由于使用了问卷，存在回忆偏倚的可能性。本研究未评估女性。
吸烟、PHG 家族史和肥胖是与 PHG 相关的重要因素。
