Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; Digital Neuropathology Laboratory, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Lewy Body Disease Center of Excellence, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; Frontotemporal Degeneration Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Neurobiol Aging. 2020 Dec;96:137-147. doi: 10.1016/j.neurobiolaging.2020.08.003. Epub 2020 Aug 21.
We compared regional retention of F-flortaucipir between 20 patients with Lewy body disorders (LBD), 12 Alzheimer's disease patients with positive amyloid positron emission tomography (PET) scans (AD+Aβ) and 15 healthy controls with negative amyloid PET scans (HC-Aβ). In LBD subjects, we compared the relationship between F-flortaucipir retention and cerebrospinal fluid (CSF) tau, cognitive performance, and neuropathological tau at autopsy. The LBD cohort was stratified using an Aβ42 cut-off of 192 pg/mL to enrich for groups likely harboring tau pathology (LBD+Aβ = 11, LBD-Aβ = 9). F-flortaucipir retention was higher in LBD+AB than HC-Aβ in five, largely temporal-parietal regions with sparing of medial temporal regions. Higher retention was associated with higher CSF total-tau levels (p = 0.04), poorer domain-specific cognitive performance (p = 0.02-0.04), and greater severity of neuropathological tau in corresponding regions. While F-flortaucipir retention in LBD is intermediate between healthy controls and AD, retention relates to cognitive impairment, CSF total-tau, and neuropathological tau. Future work in larger autopsy-validated cohorts is needed to define LBD-specific tau biomarker profiles.
我们比较了 20 例路易体疾病（LBD）患者、12 例阿尔茨海默病患者（AD+Aβ）和 15 例阴性淀粉样蛋白正电子发射断层扫描（HC-Aβ）的健康对照者之间 F-flortaucipir 的区域性保留情况。在 LBD 受试者中，我们比较了 F-flortaucipir 保留与脑脊液（CSF）tau、认知表现和尸检时神经病理学 tau 之间的关系。LBD 队列使用 Aβ42 截止值 192pg/ml 进行分层，以富集可能存在 tau 病理学的组（LBD+Aβ=11，LBD-Aβ=9）。与 HC-Aβ相比，LBD+AB 患者在五个主要是颞顶区域，而内侧颞叶区域保留较多的 F-flortaucipir 保留率较高。较高的保留率与较高的 CSF 总 tau 水平（p=0.04）、特定领域认知表现较差（p=0.02-0.04）和相应区域神经病理学 tau 严重程度较高相关。虽然 LBD 患者的 F-flortaucipir 保留率在健康对照组和 AD 之间处于中间水平，但保留率与认知障碍、CSF 总 tau 和神经病理学 tau 相关。未来需要在更大的尸检验证队列中进行研究，以确定 LBD 特异性 tau 生物标志物谱。
