Behav Brain Res. 2019 May 17;364:256-263. doi: 10.1016/j.bbr.2019.02.019. Epub 2019 Feb 12.
To determine the association between functional connectivity (FC) of functional-segmented anterior and posterior portions of the hippocampus and performance on verbal and visual memory tests in a young, healthy population.
We recruited 100 healthy participants in the age of 19-29. Resting state fMRI data were acquired and voxel-wise correlation analysis was performed to functionally divide the hippocampus. We investigated the inter-hemispheric hippocampal-cortical functional connectivity after the participants took the assessment of episodic memory using verbal (California Verbal Learning Test II, CVLT-II) and visual subtests (Rey-Osterrieth Complex Figure, ROCF). The partial correlations were used to identify the association between the intra-hemispheric hippocampal-cortical mean resting correlation and memory performance.
The results showed that the anterior and posterior hippocampal networks involved differently in verbal and visual memory. Intra-hemispheric FC between left posterior hippocampus and posterior parahippocampal gyrus (PPHG) was positively correlated with CVLT-II Trail 2 Immediate Free Recall (r = 0.223, p = 0.029). Intra-hemispheric FC between left posterior hippocampus and posterior cingulate (PCC) was negatively correlated with ROCF Immediate Recall (r = -0.217 p = 0.034). Intra-hemispheric FC between left anterior hippocampus and temporal pole (TP) negatively correlated with ROCF Delayed Recall (r = -0.228, p = 0.025). Split half resampling procedure results showed some repeatability in our subjects.
The present results demonstrated that, the anterior hippocampus was specifically involved in the visual memory processing, whereas the posterior hippocampus contributed to both the verbal and visual memories, which may have implications for a functionally synergetic and dissociable role of the hippocampus in different kinds of memory.
在年轻健康人群中，确定功能性连接（FC）在前、后海马体分段区域与言语和视觉记忆测试表现之间的相关性。
我们招募了 100 名年龄在 19-29 岁的健康参与者。采集静息状态 fMRI 数据，并进行体素相关性分析以对海马体进行功能划分。在参与者接受了基于言语（加州词语学习测验第二版，CVLT-II）和视觉子测试（Rey-Osterrieth 复杂图形，ROCFT）的情景记忆评估后，我们对半球间海马皮质功能连接进行了研究。采用偏相关分析来确定内半脑海马皮质平均静息相关与记忆表现之间的相关性。
结果表明，前、后海马网络在言语和视觉记忆中涉及的区域不同。左后海马体与后内嗅皮质（PPHG）之间的内半脑 FC 与 CVLT-II 测试 2 即时自由回忆呈正相关（r=0.223，p=0.029）。左后海马体与后扣带（PCC）之间的内半脑 FC 与 ROCFT 即时回忆呈负相关（r=-0.217，p=0.034）。左前海马体与颞极（TP）之间的内半脑 FC 与 ROCFT 延迟回忆呈负相关（r=-0.228，p=0.025）。半分割重采样程序结果表明，我们的受试者中存在一定的可重复性。
本研究结果表明，前海马体特别参与了视觉记忆处理，而后海马体则参与了言语和视觉记忆，这可能意味着海马体在不同类型的记忆中具有功能协同和可分离的作用。
