Kaslow R A, Ostrow D G, Detels R, Phair J P, Polk B F, Rinaldo C R
Am J Epidemiol. 1987 Aug;126(2):310-8. doi: 10.1093/aje/126.2.310.
The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the infection, and establish a repository of biologic specimens for future study. A variety of recruitment techniques, including special assurance of confidentiality, were used to enroll participants. Nearly 5,000 homosexual men volunteered for semiannual interview, physical examination, and laboratory testing in four metropolitan areas. A significant majority of these men in each center (69-83%) reported having 50 or more lifetime sexual partners, and over 80% had engaged in receptive anal intercourse with at least some of their partners in the previous two years. By the time of the participants' initial evaluation (April 1984-April 1985), infection with the human immunodeficiency virus (HIV) had occurred in higher proportions of men in Los Angeles (51%) and Chicago (43%) than in Baltimore/Washington, DC (31%) and Pittsburgh (21%), presumably as a result of the higher number of partners and proportion with whom these men had engaged in high-risk practices (e.g., receptive anal intercourse). Follow-up evaluations are underway in this comprehensive longitudinal investigation of HIV infection.
多中心艾滋病队列研究旨在阐明导致获得性免疫缺陷综合征（AIDS）的感染的自然史，确定该感染发生和临床表现的风险因素，并建立生物标本库以供未来研究。采用了多种招募技术，包括特殊的保密保证措施，以招募参与者。近5000名同性恋男子自愿在四个大都市地区接受半年一次的访谈、体格检查和实验室检测。每个中心的这些男子中，绝大多数（69%-83%）报告称一生中有50个或更多性伴侣，超过80%的人在过去两年中至少与部分伴侣进行过接受肛交。到参与者初次评估时（1984年4月至1985年4月），洛杉矶（51%）和芝加哥（43%）感染人类免疫缺陷病毒（HIV）的男性比例高于巴尔的摩/华盛顿特区（31%）和匹兹堡（21%），这可能是由于这些男性的性伴侣数量较多以及与他们进行高危行为（如接受肛交）的性伴侣比例较高所致。对HIV感染的这项全面纵向调查正在进行随访评估。
